Department of Physiology, Faculty of Science, University of Extremadura, Avda. Elvas s/n, 06006 Badajoz, Spain.
J Nutr Health Aging. 2013;17(6):553-60. doi: 10.1007/s12603-013-0029-4.
In the present work, we evaluated the effect of the intake of a Jerte Valley cherry-based product (JVCP), compared to a placebo product, on sleep quality, urinary 6-sulfatoxymelatonin (aMT6-s) levels and the serum concentration of interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α) and interleukin-8 (IL-8).
This was a blind, placebo-controlled, randomized, crossover study.
University of Extremadura (Spain).
Ten young (20-30 years old), ten middle-aged (35-55 years old), and ten elderly (65-85 years old) participants.
A placebo (Kool-Aid®) or JVCP (patent no. ES 2342141 B1) were consumed twice a day, as lunch and dinner desserts.
Actigraphic monitoring was used to record and display the temporal patterns of the individuals' activity and rest. Urinary aMT6-s and serum cytokines (IL-1β, TNF-α and IL-8) were also determined.
The consumption of the JVCP improved the nocturnal rest, measured by sleep efficiency, number of awakenings, total nocturnal activity, sleep latency, assumed sleep, actual sleep time and immobility. Moreover, it was detected an increase in both the levels of aMT6-s found in first-void morning urine and the concentrations of serum pro-somnogenic cytokines obtained from samples collected at the acrophase of the melatonin rhythm (1.00 am) in all experimental age groups after the JVCP consumption. Generally, better results were obtained with advancing age.
The ingestion of the JVCP may contribute to establish a high-quality sleep and be used as a potential nutraceutical tool to prevent sleep disorders with the advance of age.
本研究旨在评估摄入赫尔特山谷樱桃制品（JVCP）与安慰剂产品相比对睡眠质量、尿液 6-硫酸褪黑素（aMT6-s）水平以及血清白细胞介素-1β（IL-1β）、肿瘤坏死因子α（TNF-α）和白细胞介素-8（IL-8）浓度的影响。
这是一项双盲、安慰剂对照、随机、交叉研究。
西班牙埃斯特雷马杜拉大学。
10 名年轻（20-30 岁）、10 名中年（35-55 岁）和 10 名老年（65-85 岁）参与者。
参与者午餐和晚餐时分别食用安慰剂（Kool-Aid®）或 JVCP（专利号 ES 2342141 B1）作为甜点。
活动记录仪用于记录和显示个体活动和休息的时间模式。还测定了尿液 aMT6-s 和血清细胞因子（IL-1β、TNF-α 和 IL-8）。
与安慰剂相比，JVCP 可改善睡眠效率、觉醒次数、总夜间活动、睡眠潜伏期、假设睡眠时间、实际睡眠时间和不动时间等夜间休息参数。此外，在所有实验年龄组中，JVCP 摄入后，首次晨尿中 aMT6-s 水平和在褪黑素节律峰值（凌晨 1 点）采集的血清促睡眠细胞因子浓度均有增加。一般来说，随着年龄的增长，结果会更好。
摄入 JVCP 可能有助于建立高质量的睡眠，并可作为预防随年龄增长而出现睡眠障碍的潜在营养工具。
