Tucker Robin M, Kim Nahyun, Gurzell Eric, Mathi Sruti, Chavva Shreya, Senthilkumar Dharshini, Bartunek Olivia, Fenton Kayla C, Herndon-Fenton Sidney J, Cardino Vanessa N, Cooney Gabrielle M, Young Sam, Fenton Jenifer I
Department of Food Science and Human Nutrition, Michigan State University, 469 S. Wilson Rd., Rm 204, East Lansing, MI 48824, USA.
Department of Physical Education, Korea University, Seoul 02841, Republic of Korea.
Nutrients. 2024 Nov 28;16(23):4125. doi: 10.3390/nu16234125.
BACKGROUND/OBJECTIVES: Sleep problems are frequently experienced and play an important role in inflammation and disease risk. US Montmorency tart cherries (MTC) improve sleep outcomes in previous studies, but studies in individuals with overweight and obesity are lacking.
A total of 34 individuals with sleep issues and overweight or obesity (BMI: 32.1 ± 7.0 kg/m) were recruited to this randomized controlled, crossover study. MTC capsules (500 mg) or a placebo were taken one hour before bed for 14 days. Sleep outcomes including total sleep time, deep and REM sleep duration, nap duration, and nocturnal sleep duration were assessed using the Zmachine and/or Fitbit Inspire 3. Subjective sleep information on quality and insomnia symptoms was collected using the Pittsburgh Sleep Quality Index, the Sleep Quality Scale, and the Insomnia Severity Index. Markers of inflammation included C-reactive protein, TNF-α, and IL-6, IL-8, IL-10, and IL-17A.
No significant effects of MTC supplementation were observed for any of the measures of interest ( > 0.05 for all).
These results suggest studies of individuals with overweight and obesity should test higher doses of MTC than those currently recommended.
背景/目的：睡眠问题很常见，且在炎症和疾病风险中起重要作用。美国蒙特莫伦西酸樱桃（MTC）在先前的研究中改善了睡眠结果，但缺乏针对超重和肥胖个体的研究。
总共34名有睡眠问题且超重或肥胖（BMI：32.1±7.0kg/m²）的个体被纳入这项随机对照交叉研究。在睡前1小时服用MTC胶囊（500毫克）或安慰剂，持续14天。使用Z机和/或Fitbit Inspire 3评估睡眠结果，包括总睡眠时间、深度睡眠和快速眼动睡眠时间、小睡时间和夜间睡眠时间。使用匹兹堡睡眠质量指数、睡眠质量量表和失眠严重程度指数收集关于睡眠质量和失眠症状的主观睡眠信息。炎症标志物包括C反应蛋白、肿瘤坏死因子-α、白细胞介素-6、白细胞介素-8、白细胞介素-10和白细胞介素-17A。
对于任何感兴趣的指标，均未观察到补充MTC的显著效果（所有P>0.05）。
这些结果表明，针对超重和肥胖个体的研究应测试比目前推荐剂量更高的MTC剂量。
