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中国杭州麻疹的流行病学特征及消除麻疹的难点。

The epidemiological characteristics of measles and difficulties of measles elimination in Hang Zhou, China.

机构信息

Hangzhou Center for Disease Control and Prevention; Hangzhou, P.R. China.

出版信息

Hum Vaccin Immunother. 2013 Jun;9(6):1296-302. doi: 10.4161/hv.24032. Epub 2013 Jun 1.

Abstract

OBJECTIVE

Following the national proclaim of Measles Elimination 2012, plenty of activities for controlling the incidence had practiced in Hangzhou. However, the incidence did not decrease to low degree and remained perform as gap to the elimination target. The present study aimed to describe the epidemiological characteristics of measles, and proposed reasonable method to the target in Hangzhou.

METHOD

Cases were collected by the National Notifiable Diseases Surveillance System (NNDSS) from 2004 to 2011. The descriptive epidemiology was employed to analyze characteristics of measles.

RESULTS

A total of 4712 confirmed cases were enrolled by the NNDSS with 7.87 per 100,000 people of incidence rate on average from 2004 to 2011. Individuals lived urban districts had higher risk of measles than counties. Infants aged<1 year observed the highest incidence rate with 239.35/100,000, and the age-specific incidence rate declined along with aged-group but reversed at adults. 52.20% of cases were floating cases and the measles vaccination was significantly different from the local cases (χ(2)=51.65, p< 0.001). February to June was the epidemic period for measles incidence with 81.88% of cases reported in cluster.

CONCLUSION

The descriptive characteristics of measles suggested that factors included infant and adult individual, floating population, and living urban area might be relate to the elimination target. More efforts were need to ensure susceptible population had accepted qualified measles vaccination.

摘要

目的

2012 年全国宣布消除麻疹后,杭州市开展了大量控制发病率的活动。然而,发病率并未降至低水平,仍未达到消除目标。本研究旨在描述麻疹的流行病学特征,并为杭州市的目标提出合理的方法。

方法

通过国家法定传染病监测系统(NNDSS)收集 2004 年至 2011 年的病例。采用描述性流行病学方法分析麻疹的特征。

结果

NNDSS 共纳入 4712 例确诊病例,平均发病率为 7.87/10 万人。与农村地区相比,居住在城区的个体麻疹发病风险更高。<1 岁的婴儿麻疹发病率最高,为 239.35/10 万人,年龄别发病率随年龄组下降,但在成年人中出现逆转。52.20%的病例为流动病例,麻疹疫苗接种情况与本地病例明显不同(χ²=51.65,p<0.001)。2 月至 6 月是麻疹发病的流行期,81.88%的病例呈聚集性报告。

结论

麻疹的描述性特征表明,婴儿和成年个体、流动人口和居住在城区等因素可能与消除目标有关。需要进一步努力确保易感人群接受合格的麻疹疫苗接种。

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