氧化应激的常见生物标志物不能反映大鼠的心血管功能异常/功能。
Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats.
作者信息
Mladenka Premysl, Zatloukalova Libuse, Filipsky Tomas, Vavrova Jaroslava, Holeckova Magdalena, Palicka Vladimir, Hrdina Radomir
机构信息
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2013 Jun;157(2):146-52. doi: 10.5507/bp.2013.033. Epub 2013 May 28.
BACKGROUND
Predicting cardiovascular events remains challenging despite the range of known biomarkers.
AIM
To establish relationships between various biochemical and functional parameters of the cardiovascular system.
METHOD
The relationship between cardiovascular dys/function and various biomarkers was examined in 145 experimental rats half of which received isoprenaline 100 mg/kg s.c. to induce cardiac impairment.
RESULTS
Serum concentration of cardiac troponin T (cTnT), a known marker of cardiac derangement, correlated strongly with degree of myocardial injury (e.g. calcium overload, stroke volume) but correlations between cTnT and oxidative stress parameters were weak (for glutathione and vitamin C) or not found (for serum vitamin E and plasma thiobarbituric acid reactive substances levels). Relationships between cTnT and other parameters were exponential with the exception of myocardial calcium, where a power function was found.
CONCLUSIONS
Commonly used biomarkers of oxidative stress cannot reliably predict cardiovascular dys/function in experimental rats.
背景
尽管已知多种生物标志物，但预测心血管事件仍然具有挑战性。
目的
建立心血管系统各种生化和功能参数之间的关系。
方法
在145只实验大鼠中检测心血管功能异常/功能与各种生物标志物之间的关系，其中一半大鼠皮下注射100mg/kg异丙肾上腺素以诱导心脏损伤。
结果
心肌肌钙蛋白T（cTnT）的血清浓度是心脏紊乱的已知标志物，与心肌损伤程度（如钙超载、每搏输出量）密切相关，但cTnT与氧化应激参数之间的相关性较弱（对于谷胱甘肽和维生素C）或未发现相关性（对于血清维生素E和血浆硫代巴比妥酸反应性物质水平）。cTnT与其他参数之间的关系呈指数关系，但心肌钙除外，其呈幂函数关系。
结论
常用的氧化应激生物标志物不能可靠地预测实验大鼠的心血管功能异常/功能。
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