锌取代纳米羟基磷灰石涂层对种植体表面骨整合的影响。
Effects of zinc-substituted nano-hydroxyapatite coatings on bone integration with implant surfaces.
机构信息
Department of Oral Implantology, Affiliated Stomatology Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
出版信息
J Zhejiang Univ Sci B. 2013 Jun;14(6):518-25. doi: 10.1631/jzus.B1200327.
OBJECTIVE
The purpose of this study was to investigate the effects of a zinc-substituted nano-hydroxyapatite (Zn-HA) coating, applied by an electrochemical process, on implant osseointegraton in a rabbit model.
METHODS
A Zn-HA coating or an HA coating was deposited using an electrochemical process. Surface morphology was examined using field-emission scanning electron microscopy. The crystal structure and chemical composition of the coatings were examined using an X-ray diffractometer (XRD) and Fourier transform infrared spectroscopy (FTIR). A total of 78 implants were inserted into femurs and tibias of rabbits. After two, four, and eight weeks, femurs and tibias were retrieved and prepared for histomorphometric evaluation and removal torque (RTQ) tests.
RESULTS
Rod-like HA crystals appeared on both implant surfaces. The dimensions of the Zn-HA crystals seemed to be smaller than those of HA. XRD patterns showed that the peaks of both coatings matched well with standard HA patterns. FTIR spectra showed that both coatings consisted of HA crystals. The Zn-HA coating significantly improved the bone area within all threads after four and eight weeks (P<0.05), the bone to implant contact (BIC) at four weeks (P<0.05), and RTQ values after four and eight weeks (P<0.05).
CONCLUSIONS
The study showed that an electrochemically deposited Zn-HA coating has potential for improving bone integration with an implant surface.
目的
本研究旨在探讨通过电化学工艺施加的锌取代纳米羟基磷灰石（Zn-HA）涂层对兔模型中植入物骨整合的影响。
方法
通过电化学工艺沉积 Zn-HA 涂层或 HA 涂层。使用场发射扫描电子显微镜检查表面形态。使用 X 射线衍射仪（XRD）和傅里叶变换红外光谱（FTIR）检查涂层的晶体结构和化学成分。将总共 78 个植入物插入兔子的股骨和胫骨中。在 2、4 和 8 周后，取出股骨和胫骨并准备进行组织形态计量评估和去除扭矩（RTQ）测试。
结果
两种植入物表面均出现棒状 HA 晶体。Zn-HA 晶体的尺寸似乎小于 HA。XRD 图谱表明两种涂层的峰均与标准 HA 图谱吻合良好。FTIR 光谱表明两种涂层均由 HA 晶体组成。Zn-HA 涂层在 4 周和 8 周后显著增加了所有螺纹内的骨面积（P<0.05）、4 周时的骨植入物接触（BIC）（P<0.05）和 4 周和 8 周后的 RTQ 值（P<0.05）。
结论
本研究表明，电化学沉积的 Zn-HA 涂层具有改善植入物表面骨整合的潜力。
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