Yang Guo-li, He Fu-ming, Hu Ji-an, Wang Xiao-xiang, Zhao Shi-fang
Department of Oral and Maxillofacial Surgery, Stomatology Hospital, Medical College, Zhejiang University, Hangzhou, China.
J Oral Maxillofac Surg. 2010 Feb;68(2):420-7. doi: 10.1016/j.joms.2009.09.014.
The purpose of this study was to investigate the effects of biomimetically and electrochemically deposited hydroxyapatite on the fixation of an implant with bone tissue.
Implants were separated into 3 groups: roughened group, biomimetically deposited calcium-phosphorus (BDCaP) group, and electrochemically deposited hydroxyapatite (EDHA) group. We randomly inserted 90 implants into the femurs of 45 rabbits. After 2, 4, and 8 weeks, the femurs were retrieved and prepared for removal torque tests (RTQs) and field-emission scanning electron microscopy observation.
During the test period, the EDHA group showed significantly greater RTQ values than did the roughened group and BDCaP group. The BDCaP group failed to increase the RTQ values compared with the roughened group. Field-emission scanning electron microscopy observation showed that the amount of attached bone tissue on the EDHA-coated implant surface was more than that on the roughened and BDCaP-coated implant surfaces during the test period.
The electrochemical hydroxyapatite coating contributes to the fixation between bone and implant compared with the roughened surface, whereas the biomimetic calcium-phosphorus coating has little effect on the fixation.
本研究旨在调查仿生和电化学沉积的羟基磷灰石对植入物与骨组织固定的影响。
将植入物分为3组：粗糙组、仿生沉积钙磷（BDCaP）组和电化学沉积羟基磷灰石（EDHA）组。我们将90枚植入物随机植入45只兔子的股骨中。在2周、4周和8周后，取出股骨并准备进行去除扭矩测试（RTQ）和场发射扫描电子显微镜观察。
在测试期间，EDHA组的RTQ值明显高于粗糙组和BDCaP组。与粗糙组相比，BDCaP组未能提高RTQ值。场发射扫描电子显微镜观察显示，在测试期间，EDHA涂层植入物表面附着的骨组织量多于粗糙和BDCaP涂层植入物表面。
与粗糙表面相比，电化学羟基磷灰石涂层有助于骨与植入物之间的固定，而仿生钙磷涂层对固定作用不大。
