Meyer Barbara J, Grenyer Brin F S, Crowe Trevor, Owen Alice J, Grigonis-Deane Elizabeth M, Howe Peter R C
Metabolic Research Centre, University of Wollongong, Wollongong, NSW, 2522, Australia.
Lipids. 2013 Sep;48(9):863-8. doi: 10.1007/s11745-013-3801-7. Epub 2013 Jun 4.
The aim of this study was to determine if changes in omega-3 polyunsaturated fatty acid status following tuna oil supplementation correlated with changes in scores of depression. A total of 95 volunteers receiving treatment for major depression were randomised to consume 8 × 1 g capsules per day of HiDHA (2 g DHA, 0.6 g EPA and 10 mg Vitamin E) or olive oil (placebo) for 16 weeks, whilst undergoing weekly counseling sessions by trained clinical psychologists using a standard empirically validated psychotherapy. Depression status was assessed using the 17 item Hamilton rating scale for depression and the Beck Depression Inventory by a psychodiagnostician who was blind to the treatment. Blood was taken at baseline and 16 weeks (n = 48) for measurement of erythrocyte fatty acids. With HiDHA supplementation, erythrocyte DHA content rose from 4.1 ± 0.2 to 7.9 ± 0.4 % (mean ± SEM, p < 0.001) of total fatty acids but did not change (4.0 ± 0.2 to 4.1 ± 0.2 %) in the olive oil group. The mean changes in scores of depression did not differ significantly between the two groups (-12.2 ± 2.1 for tuna oil and -14.4 ± 2.3 for olive oil). However, analysis of covariance showed that in the fish oil group there was a significant correlation (r = -0.51) between the change in erythrocyte DHA and the change in scores of depression (p < 0.05). Further study of the relationship between DHA and depression is warranted.
本研究的目的是确定补充金枪鱼油后ω-3多不饱和脂肪酸状态的变化是否与抑郁评分的变化相关。共有95名接受重度抑郁症治疗的志愿者被随机分为两组，一组每天服用8粒1克装的高DHA胶囊（2克DHA、0.6克EPA和10毫克维生素E），另一组服用橄榄油（安慰剂），为期16周，同时由训练有素的临床心理学家使用经过实证验证的标准心理疗法每周进行一次咨询。由对治疗不知情的心理诊断师使用17项汉密尔顿抑郁评定量表和贝克抑郁量表评估抑郁状态。在基线和16周时采集血液（n = 48）以测量红细胞脂肪酸。补充高DHA后，红细胞DHA含量从总脂肪酸的4.1±0.2%升至7.9±0.4%（均值±标准误，p < 0.001），而橄榄油组未发生变化（从4.0±0.2%至4.1±0.2%）。两组抑郁评分的平均变化无显著差异（金枪鱼油组为-12.2±2.1，橄榄油组为-14.4±2.）。然而，协方差分析显示，在鱼油组中，红细胞DHA的变化与抑郁评分的变化之间存在显著相关性（r = -0.51）（p < 0.05）。有必要进一步研究DHA与抑郁之间的关系。
