Department of Family Medicine, Seoul National University Hospital, Seoul, South Korea.
Nutrition. 2013 Sep;29(9):1110-4. doi: 10.1016/j.nut.2013.02.015. Epub 2013 Jun 2.
The metabolic effects of an aloe vera gel complex (Aloe QDM complex) on people with prediabetes or early diabetes mellitus (DM) are unknown. The goal of this study was to determine the effects of Aloe QDM complex on body weight, body fat mass (BFM), fasting blood glucose (FBG), fasting serum insulin, and Homeostasis Model of Assessment - Insulin Resistance (HOMA-IR) in obese individuals with prediabetes or early DM who were not on diabetes medications.
Participants (n = 136) were randomly assigned to an intervention or a control group and evaluated at baseline and at 4 and 8 wk.
The study lost six participants in the control group and eight in the intervention group. At 8 wk, body weight (P = 0.02) and BFM (P = 0.03) were significantly lower in the intervention group. At 4 wk, serum insulin level (P = 0.04) and HOMA-IR (P = 0.047) were lower in the intervention group; they also were lower at 8 wk but with borderline significance (P = 0.09; P = 0.08, respectively). At 8 wk, FBG tended to decrease in the intervention group (P = 0.02), but the between-group difference was not significant (P = 0.16).
In obese individuals with prediabetes or early untreated DM, Aloe QDM complex reduced body weight, BFM, and insulin resistance.
关于含有库拉索芦荟凝胶复合成分（Aloe QDM 复合成分）的代谢作用对前驱糖尿病或早期糖尿病患者的影响尚未可知。本研究旨在确定 Aloe QDM 复合成分对未接受糖尿病药物治疗的前驱糖尿病或早期糖尿病肥胖患者的体重、体脂肪量（BFM）、空腹血糖（FBG）、空腹血清胰岛素和胰岛素抵抗评估的稳态模型（HOMA-IR）的影响。
将参与者（n = 136）随机分配到干预组或对照组，并在基线和 4 周及 8 周时进行评估。
在对照组中，有 6 名参与者和干预组中的 8 名参与者脱落。在 8 周时，干预组的体重（P = 0.02）和 BFM（P = 0.03）显著降低。在 4 周时，干预组的血清胰岛素水平（P = 0.04）和 HOMA-IR（P = 0.047）较低；8 周时，这些指标也较低，但具有边缘显著性（P = 0.09；P = 0.08）。8 周时，干预组的 FBG 有下降趋势（P = 0.02），但组间差异无统计学意义（P = 0.16）。
在患有前驱糖尿病或未经治疗的早期糖尿病的肥胖患者中，Aloe QDM 复合成分可降低体重、BFM 和胰岛素抵抗。
