Pérez Yolanda Y, Jiménez-Ferrer Enrique, Zamilpa Alejandro, Hernández-Valencia Marcelino, Alarcón-Aguilar Francisco J, Tortoriello Jaime, Román-Ramos Rubén
Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social, Xochitepec, Morelos, México.
Am J Chin Med. 2007;35(6):1037-46. doi: 10.1142/S0192415X07005491.
Insulin resistance, which precedes type 2 diabetes mellitus (T2DM), is a widespread pathology associated with the metabolic syndrome, myocardial ischemia, and hypertension. Finding an adequate treatment for this pathology is an important goal in medicine. The purpose of the present research was to investigate the effect of an extract from Aloe vera gel containing a high concentration of polyphenols on experimentally induced insulin resistance in mice. A polyphenol-rich Aloe vera extract (350 mg/kg) with known concentrations of aloin (181.7 mg/g) and aloe-emodin (3.6 mg/g) was administered orally for a period of 4 weeks to insulin resistant ICR mice. Pioglitazone (50 mg/kg) and bi-distilled water were used as positive and negative controls respectively. Body weight, food intake, and plasma concentrations of insulin and glucose were measured and insulin tolerance tests were performed. The insulin resistance value was calculated using the homeostasis model assessment for insulin resistance (HOMA-IR) formula. Results showed that the polyphenol-rich extract from Aloe vera was able to decrease significantly both body weight (p < 0.008) and blood glucose levels (p < 0.005) and to protect animals against unfavorable results on HOMA-IR, which was observed in the negative control group. The highest glucose levels during the insulin tolerance curve test were in the negative control group when compared to the Aloe vera extract and pioglitazone treated mice (p < 0.05). In conclusion, Aloe vera gel could be effective for the control of insulin resistance.
胰岛素抵抗先于2型糖尿病（T2DM）出现，是一种与代谢综合征、心肌缺血和高血压相关的广泛存在的病理状态。找到针对这种病理状态的适当治疗方法是医学上的一个重要目标。本研究的目的是调查富含多酚的库拉索芦荟凝胶提取物对实验诱导的小鼠胰岛素抵抗的影响。将已知芦荟苷（181.7毫克/克）和芦荟大黄素（3.6毫克/克）浓度的富含多酚的库拉索芦荟提取物（350毫克/千克）口服给予胰岛素抵抗的ICR小鼠，持续4周。分别使用吡格列酮（50毫克/千克）和双蒸水作为阳性和阴性对照。测量体重、食物摄入量以及胰岛素和葡萄糖的血浆浓度，并进行胰岛素耐量试验。使用胰岛素抵抗稳态模型评估（HOMA-IR）公式计算胰岛素抵抗值。结果表明，富含多酚的库拉索芦荟提取物能够显著降低体重（p < 0.008）和血糖水平（p < 0.005），并保护动物免受阴性对照组中观察到的HOMA-IR不利结果的影响。与库拉索芦荟提取物和吡格列酮处理的小鼠相比，胰岛素耐量曲线试验期间最高血糖水平出现在阴性对照组（p < 0.05）。总之，库拉索芦荟凝胶可能对控制胰岛素抵抗有效。
