Department of Surgical and Perioperative Sciences, Sports Medicine, Sweden; Department of Community Medicine and Rehabilitation, Rehabilitation Medicine, Sweden; Department of Community Medicine and Rehabilitation, Geriatric Medicine, Sweden.
Int J Cardiol. 2013 Oct 9;168(4):3588-93. doi: 10.1016/j.ijcard.2013.05.065. Epub 2013 Jun 2.
Hematocrit is an independent predictor of cardiovascular risk in middle and old age, but whether hematocrit is also a predictor at younger ages is presently not known. In this study, we examined whether hematocrit measured in adolescence was associated with the risk of myocardial infarction later in life.
During Swedish national conscription tests conducted between 1969 and 1978, the hematocrit was measured in 417,099 young Swedish men. The cohort was followed for subsequent myocardial infarction events through December 2010. Associations between hematocrit and myocardial infarction were accessed using Cox regression models.
During a median follow-up period of 36 years, 9322 first-time myocardial infarctions occurred within the study cohort. After adjusting for relevant confounders and potential risk factors for myocardial infarction, men with a hematocrit≥49% had a 1.4-fold increased risk of myocardial infarction compared with men with a hematocrit≤44%. This relationship was dose dependent (p<0.001 for trend) and remained consistent throughout the follow-up period.
In this cohort of young Swedish men, hematocrit was associated with the risk of myocardial infarction later in life after controlling for other coronary risk factors. The study findings indicate that hematocrit may aid future risk assessments in young individuals.
在中年和老年人群中，血细胞比容是心血管风险的独立预测因子，但目前尚不清楚血细胞比容在年轻时是否也是一个预测因子。在这项研究中，我们研究了青春期时测量的血细胞比容是否与以后生活中心肌梗死的风险相关。
在 1969 年至 1978 年期间进行的瑞典全国征兵测试中，对 417099 名年轻瑞典男性进行了血细胞比容测量。该队列通过 2010 年 12 月的后续心肌梗死事件进行随访。使用 Cox 回归模型评估血细胞比容与心肌梗死之间的关联。
在中位数为 36 年的随访期间，研究队列中有 9322 例首次心肌梗死发生。在校正了相关混杂因素和心肌梗死的潜在危险因素后，血细胞比容≥49%的男性与血细胞比容≤44%的男性相比，心肌梗死的风险增加了 1.4 倍。这种关系呈剂量依赖性（趋势 p<0.001），并且在整个随访期间保持一致。
在这项年轻的瑞典男性队列研究中，在校正其他冠心病危险因素后，血细胞比容与以后生活中心肌梗死的风险相关。研究结果表明，血细胞比容可能有助于对年轻个体进行未来的风险评估。
