膀胱肿瘤纤连蛋白对膀胱肿瘤患者的诊断价值：系统评价与荟萃分析。
Diagnostic value of bladder tumor fibronectin in patients with bladder tumor: a systematic review with meta-analysis.
机构信息
Department of Pathogenic Biology, Chong Qing Medical University, China.
出版信息
Clin Biochem. 2013 Oct;46(15):1377-82. doi: 10.1016/j.clinbiochem.2013.05.064. Epub 2013 Jun 2.
OBJECTIVES
Bladder tumor fibronectin (BTF) has been related as a promising biomarker for the early diagnosis of bladder tumor. The meta-analysis was used to establish the diagnostic value of bladder tumor fibronectin in diagnosing bladder tumor.
METHODS
Relevant literatures evaluating the value of BTF in the diagnosis of bladder tumor were searched in PubMed, Embase, China National Knowledge Infrastructure (CNKI), Technology of Chongqing (VIP), and Wan Fang Data. Summary estimates were used to evaluate the value of BTF in the diagnosis of bladder tumor by using the Meta-DiSc and STATA 11.0 statistical software.
RESULTS
The meta-analysis included 5 studies (649 patients, 291 controls). The summary estimates revealed that the pooled sensitivity was 81% (95% confidence interval [CI]: 74%-85.1%) and specificity was 80% (95%CI 74%-84%). In addition, the area under the summary ROC curve (AUC) was 0.86 (95%CI 0.82-0.89).
CONCLUSION
BTF is a potential marker for the diagnosis of bladder tumor, and more prospective studies are needed in the future.
目的
膀胱肿瘤纤连蛋白（BTF）已被认为是一种有前途的膀胱癌早期诊断标志物。本荟萃分析旨在建立膀胱肿瘤纤连蛋白在诊断膀胱癌中的诊断价值。
方法
检索 PubMed、Embase、中国知网（CNKI）、维普及万方数据库中评估 BTF 对膀胱癌诊断价值的相关文献。使用 Meta-DiSc 和 STATA 11.0 统计软件，通过 Meta-DiSc 对 BTF 在膀胱癌诊断中的价值进行评价，计算汇总估计值。
结果
荟萃分析纳入 5 项研究（649 例患者，291 例对照）。汇总估计显示，合并敏感度为 81%（95%置信区间[CI]：74%-85.1%），特异度为 80%（95%CI：74%-84%）。此外，汇总受试者工作特征曲线下面积（AUC）为 0.86（95%CI：0.82-0.89）。
结论
BTF 是膀胱癌诊断的潜在标志物，未来需要更多的前瞻性研究。
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