Department of Radiation Oncology, Washington University School of Medicine, 4921 Parkview Place, Campus Box 8224, St. Louis, MO 63110, USA.
Phys Med Biol. 2013 Jun 21;58(12):4357-66. doi: 10.1088/0031-9155/58/12/4357. Epub 2013 Jun 5.
Recent research has demonstrated that europium doped potassium chloride (KCl:Eu(2+)) storage phosphor material has the potential to become the physical foundation of a novel and reusable dosimetry system using either film-like devices or devices similar to thermoluminescent dosimeter chips. The purposes of this work are to quantify the performance of KCl:Eu(2+) prototype dosimeters for low-dose measurements and to demonstrate how it can be incorporated into clinical application for in vivo peripheral dose measurements. Pellet-style KCl:Eu(2+) dosimeters, 6 mm in diameter, and 1 mm thick, were fabricated in-house for this study. The dosimeters were read using a laboratory photostimulated luminescence detection system. KCl:Eu(2+) prototype storage phosphor dosimeter was capable of measuring a dose-to-water as low as 0.01 cGy from a 6 MV photon beam with a signal-to-noise ratio greater than 6. A pre-readout thermal annealing procedure enabled the dosimeter to be read within an hour post-irradiation. After receiving large accumulated doses (~10 kGy), the dosimeters retained linear response in the low-dose region with only a 20% loss of sensitivity comparing to a fresh sample (zero Gy history). The energy dependence encountered during low-dose peripheral measurements could be accounted for via a single point outside-field calibration per each beam quality. With further development the KCl:Eu(2+-)-based dosimeter could become a versatile and durable dosimetry tool with large dynamic range (sub-cGy to 100 Gy).
最近的研究表明,掺铕氯化钾(KCl:Eu(2+))存储磷光体材料有可能成为一种新型的、可重复使用的剂量测量系统的物理基础,无论是使用薄膜状设备还是类似于热释光剂量计芯片的设备。这项工作的目的是量化 KCl:Eu(2+)原型剂量计在低剂量测量中的性能,并展示如何将其应用于临床进行体外周围剂量测量。本研究中,制备了直径为 6 毫米、厚度为 1 毫米的 KCl:Eu(2+)原型剂量计。使用实验室光激励发光检测系统对这些剂量计进行读取。KCl:Eu(2+)原型存储磷光体剂量计能够测量 6MV 光子束低至 0.01 cGy 的剂量,信噪比大于 6。通过预读取热退火程序,剂量计可以在辐照后一小时内进行读取。在接受大剂量累积(~10 kGy)后,剂量计在低剂量区域仍保持线性响应,与新鲜样品(零 Gy 历史)相比,灵敏度仅下降 20%。在低剂量外周测量中遇到的能量依赖性可以通过对每个光束质量进行单次场外校准来解释。通过进一步开发,基于 KCl:Eu(2+)的剂量计可以成为一种具有大动态范围(亚 cGy 至 100 Gy)的通用且耐用的剂量计工具。