Department of Environmental Science, Aarhus University, Frederiksborgvej 399, Roskilde, Denmark.
Int J Environ Res Public Health. 2013 Jun 4;10(6):2271-81. doi: 10.3390/ijerph10062271.
Concentrations of pesticides and selected metabolites in rat urine and amniotic fluid were determined as biomarker upon oral administration of Wistar rats to two pesticide mixtures consisting of three to five pesticides (bitertanol, propiconazole, cypermethrin, malathion, and terbuthylazine). The pesticides and their metabolites were found in rat amniotic fluid and urine, generally in dose-response concentrations in relation to dosage. The measurement of the substances in the amniotic fluid indicated that the fetus was exposed to the pesticides as well as their metabolites. Moreover, the pesticides detected in urine demonstrated the exposure as well as the ability of the rat to excrete these compounds.
在给 Wistar 大鼠口服两种由三到五种农药（联苯三唑醇、丙环唑、氯菊酯、马拉硫磷和特丁津）组成的农药混合物后，检测了大鼠尿液和羊水中的农药浓度和选定代谢物浓度，作为生物标志物。通常情况下，这些农药及其代谢物在与剂量相关的剂量反应浓度下存在于大鼠的羊水和尿液中。在羊水中测量这些物质表明胎儿也接触到了这些农药及其代谢物。此外，尿液中检测到的农药表明大鼠接触了这些化合物，并且有能力将其排出体外。
