School of Pharmacy, College of Medicine, National Taiwan University, 1, Sec. 1, Jen-Ai Rd., Taipei 100, Taiwan.
Molecules. 2013 Jun 4;18(6):6573-83. doi: 10.3390/molecules18066573.
Three novel C19 homolignans, taiwankadsurins D (1), E (2) and F (4), and two new C18 lignans kadsuphilins N (3) and O (5) were isolated from the aerial parts of Taiwanese medicinal plant Kadsura philippinensis. The structures of compounds 1-5 were determined by spectroscopic analyses, especially 2D NMR techniques. The structure of compound 5 was further confirmed by X-ray crystallographic analysis. Compounds 1 and 2 have a 3,4-{1'-[(Z)-2''-methoxy-2''-oxoethylidene]}-pentano(2,3-dihydrobenzo[b]furano)-3-(2'''-methoxycarbonyl-2'''-hydroxy-2''',3'-epoxide) skeleton.
从台湾药用植物 Kadsuphilippinensis 的地上部分分离得到三个新的 C19 木脂素类化合物 taiwankadsurins D（1）、E（2）和 F（4），以及两个新的 C18 木脂素类化合物 kadsuphilins N（3）和 O（5）。通过光谱分析，特别是二维 NMR 技术确定了化合物 1-5 的结构。通过 X 射线晶体学分析进一步确定了化合物 5 的结构。化合物 1 和 2 具有 3,4-{(1'-[(Z)-2''-甲氧基-2''-氧代亚乙基]}-戊烷(2,3-二氢苯并[b]呋喃)-3-(2'''-甲氧基羰基-2'''-羟基-2''',3'-环氧)骨架。
