Shen Ya-Ching, Cheng Yuan-Bin, Lan Ting-Wei, Liaw Chia-Ching, Liou Shorong-Shii, Kuo Yao-Haur, Khalil Ashraf Taha
School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan 100, Republic of China.
J Nat Prod. 2007 Jul;70(7):1139-45. doi: 10.1021/np078006q. Epub 2007 Jul 4.
Eight new oxygenated lignans, kadsuphilols A-H (1-8), were isolated from the leaves and stems of Kadsura philippinensis. Four of the isolated lignans (1-4) possess the normal C18-dibenzocyclooctadiene skeleton, while the other four lignans (5-8) are C19-homolignans possessing a substituted cyclohexadienone ring with a spiro-benzofuranoid moiety. The structures of the isolated metabolites were elucidated through spectroscopic analyses, including 2D NMR experiments. Compounds 1 and 4 are the first report of an R-biphenyl configuration with a beta-oxygenated substituent at the C-9 position. The in vitro radical-scavenging activities of these compounds using DPPH were tested and evaluated. Compound 3 exhibited more potent activity than vitamins C and E.
从菲律宾南五味子的叶和茎中分离出8种新的氧化木脂素，即菲律宾南五味子醇A - H（1 - 8）。分离得到的木脂素中有4种（1 - 4）具有正常的C18 - 二苯并环辛二烯骨架，而另外4种木脂素（5 - 8）是C19 - 高木脂素，具有一个带有螺苯并呋喃部分的取代环己二烯酮环。通过光谱分析，包括二维核磁共振实验，阐明了分离得到的代谢产物的结构。化合物1和4是首次报道在C - 9位具有β - 氧化取代基的R - 联苯构型。使用DPPH对这些化合物的体外自由基清除活性进行了测试和评估。化合物3表现出比维生素C和E更强的活性。
