Chen Dao-Feng, Zhang Shun-Xiang, Kozuka Mutsuo, Sun Quan-Zhong, Feng Ju, Wang Qiang, Mukainaka Teruo, Nobukuni Yoshitaka, Tokuda Harukuni, Nishino Hoyoku, Wang Hui-Kang, Morris-Natschke Susan L, Lee Kuo-Hsiung
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.
J Nat Prod. 2002 Sep;65(9):1242-5. doi: 10.1021/np0105127.
Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Raji cells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds. These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
从内南五味子茎中分离得到两个新的木脂素，内南五味子素C（1）和D（2），以及已知化合物内南五味子素（3）、异形南五味子素F（4）、新卡德苏兰宁（5）、异形南五味子素D（6）、卡德苏兰宁（7）、戈米辛A（8）、五味子丙素（9）、内南五味子素A（10）、当归酰戈米辛R（11）、戈米辛G（12）、内南五味子素B（13）和戈米辛C（14）。通过质谱、圆二色谱和核磁共振光谱数据确定了新化合物的结构和立体化学。通过检测十四种新木脂素对拉吉细胞中爱泼斯坦-巴尔病毒早期抗原（EBV-EA）激活（由12-O-十四烷酰佛波醇-13-乙酸酯诱导）的抑制能力，筛选它们作为潜在的抗肿瘤促癌剂。新卡德苏兰宁（5）和五味子丙素（9）是最有效的化合物。这些数据表明，一些新木脂素可能是有价值的抗肿瘤促癌剂或化学预防剂。
