Internal Medicine, The Ottawa Hospital, Ottawa, ON.
Curr Oncol. 2013 Jun;20(3):e270-3. doi: 10.3747/co.20.1212.
Spontaneous regression of metastatic melanoma is an exceedingly rare event, with only 76 well-documented cases in the literature since 1866. Here, we present the case of a patient who developed metastatic melanoma despite interferon therapy and who then achieved spontaneous regression shortly after a reaction to tetanus-diphtheria-pertussis vaccination. A common theme among these cases is the development of febrile illness before remission of the malignant disease. A brief overview of proposed mechanisms for these miraculous recoveries is presented, including a highlight on the potential role of the herv-k-mel viral marker, a nona- or decapeptide that appears in most melanomas, with homologies to peptides in pathogenic microorganisms.
转移性黑色素瘤的自发消退是一种极其罕见的现象，自 1866 年以来，文献中仅有 76 例经过充分证实的病例。在此，我们报告了 1 例患者的病例，该患者尽管接受了干扰素治疗，但仍发生了转移性黑色素瘤，随后在破伤风、白喉和百日咳疫苗接种反应后不久即出现了自发消退。这些病例的一个共同主题是在恶性疾病缓解之前出现发热性疾病。本文简要概述了这些奇迹般恢复的可能机制，包括对 herv-k-mel 病毒标志物（一种存在于大多数黑色素瘤中的九肽或十肽，与致病性微生物中的肽具有同源性）潜在作用的强调。
