Hu Guangmei, Xu Xinjuan, Liang Xiaohui, Yang Xiaoping, Zhang Junshi, Simayi Zhulepiya, Chen Yulan
State Key Laboratory Incubation Base of Xinjiang Major Diseases Research;
Exp Ther Med. 2013 May;5(5):1439-1443. doi: 10.3892/etm.2013.991. Epub 2013 Mar 6.
This study aimed to investigate the associations among the levels of plasma atrial natriuretic peptide (ANP) and electrolytes and essential hypertension (EH) in Uygur, Han and Kazakh populations in Xinjiang. A total of 724 hypertensive participants of different ethnicities from Xinjiang (208 Uygur, 287 Han and 229 Kazakh) and 741 normal controls (208 Uygur, 267 Han and 266 Kazakh) were enrolled. The associations of ANP with serum potassium, serum sodium and blood pressure were assessed. In the normal control (NT) group, the concentration of ANP was higher in the Uygur population than in the Han population, and the concentration in the Han population was higher than that in the Kazakh population (P<0.05). In the EH group, the serum potassium levels of the Uygur and Han populations were higher than that of the Kazakh population (P<0.05). The ANP concentration in the Uygur ethnic group was higher than that in the Han population, which was in turn higher than that in the Kazakh participants (P<0.05). In the Kazakh population, the serum potassium level was significantly lower in the EH group compared with that in the NT group (P<0.05). The serum potassium level was significantly lower and the ANP concentration significantly higher in the EH group compared with those of NT groups in the Uygur and Han populations (P<0.05). Age and body mass index (BMI) were associated with hypertension in the Uygur, Han and Kazakh populations. Low serum potassium may be a risk factor of hypertension in individuals of Uygur and Kazakh ethnicity. Plasma ANP may be a regulatory factor involved in the development of hypertension in Uygur and Han populations.
本研究旨在探讨新疆维吾尔族、汉族和哈萨克族人群中血浆心钠素（ANP）水平、电解质与原发性高血压（EH）之间的关联。共纳入724名来自新疆不同民族的高血压患者（维吾尔族208例、汉族287例、哈萨克族229例）和741名正常对照者（维吾尔族208例、汉族267例、哈萨克族266例）。评估了ANP与血清钾、血清钠及血压之间的关联。在正常对照组（NT）中，维吾尔族人群的ANP浓度高于汉族人群，汉族人群的浓度高于哈萨克族人群（P<0.05）。在EH组中，维吾尔族和汉族人群的血清钾水平高于哈萨克族人群（P<0.05）。维吾尔族人群的ANP浓度高于汉族人群，汉族人群又高于哈萨克族参与者（P<0.05）。在哈萨克族人群中，EH组的血清钾水平显著低于NT组（P<0.05）。与维吾尔族和汉族人群的NT组相比，EH组的血清钾水平显著降低，ANP浓度显著升高（P<0.05）。年龄和体重指数（BMI）与维吾尔族、汉族和哈萨克族人群的高血压有关。低血清钾可能是维吾尔族和哈萨克族个体患高血压的危险因素。血浆ANP可能是参与维吾尔族和汉族人群高血压发生发展的调节因子。
