Sun Ling, Zou Ting, Wang Bao-Zhu, Liu Fen, Yuan Qing-Hua, Ma Yi-Tong, Ma Xiang
Department of Cardiology, First Affiliated Hospital of Xingjiang Medical University, Urumqi, China.
Department of Cardiology, Fifth Affiliated Hospital of Xinjiang Medical University, Department of Cardiology, Henan, Urumqi, China.
PLoS One. 2018 Jan 18;13(1):e0188546. doi: 10.1371/journal.pone.0188546. eCollection 2018.
The prevalence of and risk factors for IAD among different ethnicity groups was unknown. Our aim was to investigate the prevalence of and risk factors for IAD among Han, Uygur and Kazakh ethnicities in Xinjiang. China.
In total, 14,618 adult participants (7,799 males and 6,819 females) were recruited from the Cardiovascular Risk Survey. A 4-stage stratified cluster random sampling method was used. The participants' personal information and medical history were assessed by questionnaire. IAD was diagnosed by a noninvasive arteriosclerosis analyzer.
The prevalence of abnormal IAD among the general population was 14.3%, with 12.5% in the Han, 14.9% in the Uygur, and 16.4% in the Kazakh populations. The prevalence of abnormal IAD among the hypertensive population was 19.4%, with 17.0% in the Han, 18.1% in the Uygur, and 22.7% in the Kazakh populations. The prevalence of abnormal IAD increased with age (all P < 0.01) but was not significantly different between the genders (all P> 0.05). Multivariate logistic regression analysis showed that age more than 45 years, obesity and hypertriglyceridemia were significantly associated with a higher prevalence of IAD. There were different risk factors for abnormal IAD in different ethnicities. Middle or old age, obesity, ABI and diabetes mellitus were risk factors for the Han population, smoking was a risk factor in the Uygur population, and obesity and PAD were risk factors in the Kazakh population.
The prevalence of abnormal IAD in the Kazakh participants was higher than that in the Han and Uygur populations among both the general population and the hypertensive population in Xinjiang, China. The main risk factors of IAD were age, obesity, and triglyceride levels. Different ethnicities had different kinds of risk factors for IAD.
不同种族群体中动脉僵硬度指数（IAD）的患病率及危险因素尚不清楚。我们的目的是调查中国新疆汉族、维吾尔族和哈萨克族人群中IAD的患病率及危险因素。
总共从心血管风险调查中招募了14618名成年参与者（7799名男性和6819名女性）。采用四阶段分层整群随机抽样方法。通过问卷调查评估参与者的个人信息和病史。使用无创动脉硬化分析仪诊断IAD。
普通人群中IAD异常的患病率为14.3%，汉族为12.5%，维吾尔族为14.9%，哈萨克族为16.4%。高血压人群中IAD异常的患病率为19.4%，汉族为17.0%，维吾尔族为18.1%，哈萨克族为22.7%。IAD异常的患病率随年龄增加而升高（所有P<0.01），但性别之间无显著差异（所有P>0.05）。多因素逻辑回归分析表明，年龄大于45岁、肥胖和高甘油三酯血症与IAD患病率较高显著相关。不同种族中IAD异常的危险因素不同。中老年、肥胖、踝臂指数（ABI）和糖尿病是汉族人群的危险因素，吸烟是维吾尔族人群的危险因素，肥胖和外周动脉疾病（PAD）是哈萨克族人群的危险因素。
在中国新疆，普通人群和高血压人群中，哈萨克族参与者IAD异常的患病率高于汉族和维吾尔族人群。IAD的主要危险因素是年龄、肥胖和甘油三酯水平。不同种族IAD的危险因素种类不同。
