Second Department of Internal Medicine, Kansai Medical University, Moriguchi City 570-8507, Japan.
Oxid Med Cell Longev. 2013;2013:796891. doi: 10.1155/2013/796891. Epub 2013 Apr 30.
Oxidative stress has been implicated in pathophysiology of aging and age-associated disease. Antioxidative medicine has become a practice for prevention of atherosclerosis. However, limited success in preventing cardiovascular disease (CVD) in individuals with atherosclerosis using general antioxidants has prompted us to develop a novel antioxidative strategy to prevent atherosclerosis. Reducing visceral adipose tissue by calorie restriction (CR) and regular endurance exercise represents a causative therapy for ameliorating oxidative stress. Some of the recently emerging drugs used for the treatment of CVD may be assigned as site-specific antioxidants. CR and exercise mimetic agents are the choice for individuals who are difficult to continue CR and exercise. Better understanding of molecular and cellular biology of redox signaling will pave the way for more effective antioxidative medicine for prevention of CVD and prolongation of healthy life span.
氧化应激与衰老和与年龄相关疾病的病理生理学有关。抗氧化药物已成为预防动脉粥样硬化的一种手段。然而，使用一般抗氧化剂预防动脉粥样硬化患者的心血管疾病（CVD）的效果有限，促使我们开发一种新的抗氧化策略来预防动脉粥样硬化。通过热量限制（CR）和定期耐力运动减少内脏脂肪组织代表了改善氧化应激的因果治疗方法。一些最近用于治疗 CVD 的新兴药物可能被指定为特定部位的抗氧化剂。对于难以继续进行 CR 和运动的个体，CR 和运动模拟剂是首选。更好地了解氧化还原信号的分子和细胞生物学将为预防 CVD 和延长健康寿命的更有效的抗氧化药物铺平道路。
