用于肌腱再生的可生物降解合成支架
Biodegradable synthetic scaffolds for tendon regeneration.
作者信息
Reverchon Ernesto, Baldino Lucia, Cardea Stefano, De Marco Iolanda
机构信息
Department of Industrial Engineering, University of Salerno, Italy.
出版信息
Muscles Ligaments Tendons J. 2012 Oct 16;2(3):181-6. Print 2012 Jul.
Abstract
Tissue regeneration is aimed at producing biological or synthetic scaffolds to be implanted in the body for regenerate functional tissues. Several techniques and materials have been used to obtain biodegradable synthetic scaffolds, on which adhesion, growth, migration and differentiation of human cells has been attempted. Scaffolds for tendon regeneration have been less frequently proposed, because they have a complex hierarchical structure and it is very difficult to mimic their peculiar mechanical properties. In this review, we critically analyzed the proposed materials and fabrication techniques for tendon tissue engineering and we indicated new preparation processes, based on the use of supercritical fluids, to produce scaffolds with characteristics very similar to the native tendon structure.
摘要
组织再生旨在制造生物或合成支架，将其植入体内以再生功能组织。已经使用了多种技术和材料来制备可生物降解的合成支架，并尝试使人细胞在其上进行黏附、生长、迁移和分化。用于肌腱再生的支架较少被提出，因为它们具有复杂的层次结构，并且很难模拟其独特的力学性能。在本综述中，我们批判性地分析了用于肌腱组织工程的材料和制造技术，并指出了基于超临界流体使用的新制备工艺，以生产具有与天然肌腱结构非常相似特征的支架。
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