Bogucka-Kocka Anna, Woźniak Michał, Feldo Marcin, Kockic Janusz, Szewczyk Katarzyna
Chair and Department of Pharmaceutical Botany, Medical University, Lublin, 20-093 Chodźki 1, Poland.
Nat Prod Commun. 2013 Apr;8(4):545-50.
Diosmin is a naturally occurring flavone glycoside used in the treatment of venous diseases. In this review, we present the clinical aspects of the use of diosmin preparations in venous stasis, hemorrheologic disorders and vein wall remodeling. Because of its multiple applications in biology and its many therapeutic activities, research on isolation and identification of diosmin is of high relevance. The aim of this review is to present an overview of techniques of isolation and separation of diosmin in plant material, pharmaceutical formulations such as Daflon, Diosed and Dioven tablets, and biological fluids.
地奥司明是一种天然存在的黄酮糖苷，用于治疗静脉疾病。在本综述中，我们介绍了地奥司明制剂在静脉淤滞、血液流变学紊乱和静脉壁重塑方面的临床应用情况。由于其在生物学中的多种应用及其众多治疗活性，地奥司明的分离与鉴定研究具有高度相关性。本综述的目的是概述从植物材料、诸如达弗隆、迪奥斯德和迪奥文片等药物制剂以及生物流体中分离和提纯地奥司明的技术。
