Regenics AS, PO Box 4536, Nydalen, 0404, Oslo, Norway.
Int J Cosmet Sci. 2013 Oct;35(5):515-22. doi: 10.1111/ics.12071. Epub 2013 Jul 6.
There is an increasing demand for scientifically documented over-the-counter products on the cosmetic market. Salmon eggs are rich in proteins, vitamins and minerals with anti-oxidative and anti-inflammatory properties, as well as free amino acids and lipids documented to be beneficial for skin. Of the fatty acids, several are commonly used as skin penetration enhancers. The unique combination of active substances led us to study whether an extract from salmon eggs could serve as an ingredient for skin care.
We conducted a double-blinded, randomized clinical trial with 66 healthy female volunteers. Efficacy of the salmon egg extract was evaluated at concentrations of 1% and 5% in vehicle formulation, and responses after 7, 14, 28 and 56 days of treatment were compared with baseline. Composition of the extract was analysed to improve the understanding of the effects of the extract on skin. The salmon egg extract was safety-tested by repeat insult patch test.
Treatment of facial skin with the salmon egg extract significantly improved all parameters investigated, wrinkles, pigmentation, redness, brightness and hydration and led to global improvement of the facial skin. Efficacy of the extract was dose dependent and time dependent. There were no adverse reactions noted during the course of the repeat insult patch test, demonstrating that the extract causes neither skin irritation nor sensitization. Furthermore, chemical analyses of the extract revealed the composition of a vast number of active substances, including unsaturated fatty acids, vitamins, proteins, minerals, DNA and RNA.
The salmon egg extract serves as a skin care ingredient that significantly improves characteristics important for perception of skin ageing and health. The efficacy of the treatment is conceivably accounted for by the unique combination of numerous active substances present in the salmon egg extract.
化妆品市场对具有科学依据的非处方产品的需求日益增长。三文鱼卵富含蛋白质、维生素和矿物质，具有抗氧化和抗炎特性，以及已被证明对皮肤有益的游离氨基酸和脂质。在脂肪酸中，有几种常用作皮肤渗透增强剂。这些活性物质的独特组合促使我们研究三文鱼卵提取物是否可以作为护肤品的成分。
我们对 66 名健康的女性志愿者进行了一项双盲、随机临床试验。在载体配方中，以 1%和 5%的浓度评估三文鱼卵提取物的功效，并与基线相比，比较了治疗 7、14、28 和 56 天后的反应。分析提取物的成分，以加深对提取物对皮肤影响的理解。通过重复损伤斑贴试验对三文鱼卵提取物进行安全性测试。
用三文鱼卵提取物对面部皮肤进行治疗，显著改善了所有研究参数，包括皱纹、色素沉着、发红、亮度和水分，并导致面部皮肤整体改善。提取物的功效具有剂量依赖性和时间依赖性。在重复损伤斑贴试验过程中没有注意到不良反应，这表明提取物既不会引起皮肤刺激，也不会引起过敏。此外，对提取物的化学分析揭示了大量活性物质的组成，包括不饱和脂肪酸、维生素、蛋白质、矿物质、DNA 和 RNA。
三文鱼卵提取物可作为护肤品成分，显著改善对皮肤老化和健康重要的特征。这种治疗的功效可以归因于三文鱼卵提取物中存在的许多活性物质的独特组合。
