Departamento de Farmácia, Setor de Ciências da Saúde, Universidade Federal do Paraná, Curitiba, PR.
Rev Soc Bras Med Trop. 2013 Mar-Apr;46(2):135-40. doi: 10.1590/0037-8682-0024-2012.
The objective of this study was to evaluate the 2009 Pandemic Influenza A (H1N1) in the elderly and identify the clinical characteristics, mortality and prognostic factors of the infection in these patients.
This was an observational, retrospective study. Data were collected from the National Notifiable Diseases (SINAN), from the Brazilian Ministry of Health. Only patients 60 years old or more that had laboratory confirmed infections were included. The socio-demographic and clinical variables and outcomes were evaluated to compare mortality rates in the presence or absence of these factors.
We included 93 patients in the study, 16.1% of whom died. The symptoms of cough and dyspnea, the use of the antiviral oseltamivir, influenza vaccine and comorbidities influenced the outcomes of cure or death. Chest radiography can aid in diagnosis.
Although relatively few elderly people were infected, this population presented high lethality that can be justified by the sum of clinical, physical and immunological factors in this population. Treatment with oseltamivir and vaccination against seasonal influenza have significantly reduced rates of hospitalization and mortality.
本研究旨在评估 2009 年甲型 H1N1 流感大流行在老年人中的情况，并确定这些患者感染的临床特征、死亡率和预后因素。
这是一项观察性、回顾性研究。数据来自巴西卫生部的国家法定传染病（SINAN）。仅纳入实验室确诊感染且年龄在 60 岁及以上的患者。评估社会人口统计学和临床变量以及结局，以比较存在或不存在这些因素时的死亡率。
本研究纳入了 93 例患者，其中 16.1%死亡。咳嗽和呼吸困难的症状、使用抗病毒药物奥司他韦、流感疫苗和合并症影响了治愈或死亡的结局。胸部 X 线检查有助于诊断。
尽管感染的老年人相对较少，但该人群的病死率较高，这可能与该人群的临床、身体和免疫因素综合作用有关。奥司他韦治疗和季节性流感疫苗接种显著降低了住院和死亡的发生率。
