Translational Genomics Unit, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Via La Masa 19, 20159 Milano, Italy.
Bioinformatics. 2013 Jul 15;29(14):1825-6. doi: 10.1093/bioinformatics/btt292. Epub 2013 Jun 5.
Pathway Processor 2.0 is a web application designed to analyze high-throughput datasets, including but not limited to microarray and next-generation sequencing, using a pathway centric logic. In addition to well-established methods such as the Fisher's test and impact analysis, Pathway Processor 2.0 offers innovative methods that convert gene expression into pathway expression, leading to the identification of differentially regulated pathways in a dataset of choice.
Pathway Processor 2.0 is available as a web service at http://compbiotoolbox.fmach.it/pathwayProcessor/. Sample datasets to test the functionality can be used directly from the application.
Supplementary data are available at Bioinformatics online.
Pathway Processor 2.0 是一个网络应用程序，旨在使用以通路为中心的逻辑分析高通量数据集，包括但不限于微阵列和下一代测序。除了 Fisher 检验和影响分析等成熟方法外，Pathway Processor 2.0 还提供了将基因表达转化为通路表达的创新方法，从而可以在选择的数据集识别差异调节的通路。
Pathway Processor 2.0 作为一个网络服务，可在 http://compbiotoolbox.fmach.it/pathwayProcessor/ 上使用。可以直接从应用程序中使用示例数据集来测试功能。
补充数据可在 Bioinformatics 在线获取。
