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本文引用的文献

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Increasing expression of microRNA 181 inhibits porcine reproductive and respiratory syndrome virus replication and has implications for controlling virus infection.microRNA 181 的表达增加抑制猪繁殖与呼吸综合征病毒复制，并对控制病毒感染具有重要意义。
J Virol. 2013 Jan;87(2):1159-71. doi: 10.1128/JVI.02386-12. Epub 2012 Nov 14.
2
Regulation of cyclin T1 and HIV-1 Replication by microRNAs in resting CD4+ T lymphocytes.微 RNA 对静息 CD4+T 淋巴细胞中环细胞 T1 和 HIV-1 复制的调控。
J Virol. 2012 Mar;86(6):3244-52. doi: 10.1128/JVI.05065-11. Epub 2011 Dec 28.
3
Increase of CD163 but not sialoadhesin on cultured peripheral blood monocytes is coordinated with enhanced susceptibility to porcine reproductive and respiratory syndrome virus infection.培养的外周血单核细胞上CD163而非唾液酸黏附素的增加与对猪繁殖与呼吸综合征病毒感染易感性增强相关。
Vet Immunol Immunopathol. 2011 Jun 15;141(3-4):209-20. doi: 10.1016/j.vetimm.2011.03.001. Epub 2011 Mar 9.
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A brief review of CD163 and its role in PRRSV infection.CD163 及其在 PRRSV 感染中的作用简述。
Virus Res. 2010 Dec;154(1-2):98-103. doi: 10.1016/j.virusres.2010.07.018. Epub 2010 Jul 23.
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Novel strategies and approaches to develop the next generation of vaccines against porcine reproductive and respiratory syndrome virus (PRRSV).开发新一代针对猪繁殖与呼吸综合征病毒 (PRRSV) 的疫苗的新策略和方法。
Virus Res. 2010 Dec;154(1-2):141-9. doi: 10.1016/j.virusres.2010.07.020. Epub 2010 Jul 23.
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Regulation of mRNA translation and stability by microRNAs.miRNAs 对 mRNA 翻译和稳定性的调控。
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Tandem affinity purification of miRNA target mRNAs (TAP-Tar).miRNA 靶 mRNA 的串联亲和纯化（TAP-Tar）。
Nucleic Acids Res. 2010 Mar;38(4):e20. doi: 10.1093/nar/gkp1100. Epub 2009 Dec 2.
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The role of RNAi and microRNAs in animal virus replication and antiviral immunity.RNA干扰和微小RNA在动物病毒复制及抗病毒免疫中的作用
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微小 RNA181 通过靶向猪繁殖与呼吸综合征病毒（PRRSV）受体 CD163 抑制 PRRSV 感染。

MicroRNA 181 suppresses porcine reproductive and respiratory syndrome virus (PRRSV) infection by targeting PRRSV receptor CD163.

机构信息

State Key Laboratory of Agrobiotechnology, China Agricultural University, Beijing, China.

出版信息

J Virol. 2013 Aug;87(15):8808-12. doi: 10.1128/JVI.00718-13. Epub 2013 Jun 5.

DOI:10.1128/JVI.00718-13
PMID:23740977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3719804/
Abstract

We previously showed that microRNA 181 (miR-181) can inhibit PRRSV replication by directly targeting its genomic RNA. Here, we report that miR-181 can downregulate the PRRSV receptor CD163 in blood monocytes and porcine alveolar macrophages (PAMs) through targeting the 3' untranslated region (UTR) of CD163 mRNA. Downregulation of CD163 leads to the inhibition of PRRSV entry into PAMs and subsequently suppresses PRRSV infection. Our findings indicate that delivery of miR-181 can be used as antiviral therapy against PRRSV infection.

摘要

我们之前的研究表明，微小 RNA 181（miR-181）可以通过直接靶向其基因组 RNA 来抑制 PRRSV 的复制。在这里，我们报告称，miR-181 可以通过靶向 CD163 mRNA 的 3'非翻译区（UTR）下调血液单核细胞和猪肺泡巨噬细胞（PAMs）中的 PRRSV 受体 CD163。CD163 的下调导致 PRRSV 进入 PAMs 的抑制，从而抑制 PRRSV 感染。我们的研究结果表明，miR-181 的递送可用作针对 PRRSV 感染的抗病毒治疗。