Pei Yangli, Lin Chenghong, Li Hua, Feng Zheng
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education Institutes, School of Life Science and Engineering, Foshan University, Foshan, China.
Front Vet Sci. 2023 Oct 20;10:1289570. doi: 10.3389/fvets.2023.1289570. eCollection 2023.
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious and economically significant virus that causes respiratory and reproductive diseases in pigs. It results in reduced productivity and increased mortality in pigs, causing substantial economic losses in the industry. Understanding the factors affecting pig responses to PRRSV is crucial to develop effective control strategies. Genetic background has emerged as a significant determinant of susceptibility and resistance to PRRSV in pigs. This review provides an overview of the basic infection process of PRRSV in pigs, associated symptoms, underlying immune mechanisms, and roles of noncoding RNA and alternative splicing in PRRSV infection. Moreover, it emphasized breed-specific variations in these aspects that may have implications for individual treatment options.
猪繁殖与呼吸综合征病毒（PRRSV）是一种极具传染性且在经济上具有重要意义的病毒，可导致猪的呼吸道和繁殖疾病。它会降低猪的生产力并增加死亡率，给该行业造成巨大经济损失。了解影响猪对PRRSV反应的因素对于制定有效的控制策略至关重要。遗传背景已成为猪对PRRSV易感性和抗性的重要决定因素。本文综述了PRRSV在猪体内的基本感染过程、相关症状、潜在免疫机制以及非编码RNA和可变剪接在PRRSV感染中的作用。此外，还强调了这些方面的品种特异性差异，这些差异可能对个体治疗方案具有重要意义。
