Guo Ze, Zhou Bingrong, Li Wei, Sun Xuejun, Luo Dan
Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China;
J Biomed Res. 2012 Sep;26(5):365-71. doi: 10.7555/JBR.26.20110037. Epub 2012 Apr 24.
Exposure of skin to solar ultraviolet (UV) radiation induces photo-damage. Ultraviolet B (UVB) is the major component of UV radiation which induces the production of reactive oxygen species (ROS) and plays an important role in photo-damage. Hydrogen gas reduces ROS and alleviates inflammation. In this study, we sought to demonstrate that hydrogen-rich saline has the effect on skin injuries caused by UVB radiation. UVB radiation was irradiated on female C57BL/6 rats to induce skin injury. Hydrogen-rich saline and nitrogen-rich saline were administered to rats by intraperitoneal injection. Skin damage was detected by microscope after injury. UVB radiation had a significant affection in tumor necrosis factor alpha, interleukin (IL)-1β and IL-6 levels, tissue superoxide dismutase, malondialdehyde and nitric oxide activity. Hydrogen-rich saline had a protective effect by altering the levels of these markers and relieved morphological skin injury. Hydrogen-rich saline protected against UVB radiation injury, possibly by reducing inflammation and oxidative stress.
皮肤暴露于太阳紫外线（UV）辐射会导致光损伤。紫外线B（UVB）是紫外线辐射的主要成分，它可诱导活性氧（ROS）的产生，并在光损伤中起重要作用。氢气可减少ROS并减轻炎症。在本研究中，我们试图证明富氢盐水对UVB辐射引起的皮肤损伤具有影响。对雌性C57BL/6大鼠进行UVB辐射以诱导皮肤损伤。通过腹腔注射将富氢盐水和富氮盐水给予大鼠。损伤后通过显微镜检测皮肤损伤情况。UVB辐射对肿瘤坏死因子α、白细胞介素（IL）-1β和IL-6水平、组织超氧化物歧化酶、丙二醛和一氧化氮活性有显著影响。富氢盐水通过改变这些标志物的水平具有保护作用，并减轻了皮肤形态学损伤。富氢盐水可能通过减轻炎症和氧化应激来预防UVB辐射损伤。
