降香黄檀心材对 RAW 264.7 巨噬细胞一氧化氮生成的抑制成分。
Inhibitory constituents of the heartwood of Dalbergia odorifera on nitric oxide production in RAW 264.7 macrophages.
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2013 Jul 15;23(14):4263-6. doi: 10.1016/j.bmcl.2013.04.032. Epub 2013 Apr 24.
Two new isoflavanones (1 and 13), along with 25 known compounds (2-12, 14-27), were isolated from the EtOAc-soluble fraction of the heartwood of Dalbergia odorifera by following their potential to inhibit the LPS-induced nitric oxide production in RAW 264.7 cells. The structures of the isolated compounds were established by spectroscopic data such as (1)D, (2)D NMR and MS spectrometry. Among the isolated compounds, (2S)-pinocembrin (26), showed the most potent inhibitory effect with IC50 value of 18.1μM.
从紫檀心材的乙酸乙酯可溶部分中，通过其抑制 LPS 诱导的 RAW 264.7 细胞中一氧化氮产生的潜力，分离得到了两种新的异黄酮（1 和 13）和 25 种已知化合物（2-12、14-27）。通过光谱数据（如（1）D、（2）D NMR 和 MS 光谱）确定了分离化合物的结构。在分离得到的化合物中，（2S）-松脂素（26）表现出最强的抑制作用，IC50 值为 18.1μM。
Zotero 插件