Department of Pathology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA 19104, USA.
Cancer Lett. 2013 Aug 28;337(1):41-8. doi: 10.1016/j.canlet.2013.05.038. Epub 2013 Jun 3.
The tight junction is a multi-protein complex and is the apical most junctional complex in certain epithelial and endothelial cells. A great deal of attention has been devoted to the understanding of these proteins in contributing to the barrier function - that is, regulating the paracellular flux or permeability between adjacent cells. However, tight junction proteins are now recognized as having functions beyond the barrier. The focus of this review is to discuss the barrier function of the tight junction and to summarize the literature with a focus on the role of tight junction proteins in proliferation, transformation, and metastasis.
紧密连接是一种多蛋白复合体，是某些上皮细胞和内皮细胞中最顶端的连接复合体。人们非常关注这些蛋白质在促进屏障功能方面的作用，即调节相邻细胞之间的旁细胞通量或通透性。然而，现在人们已经认识到紧密连接蛋白具有超越屏障的功能。本文的重点是讨论紧密连接的屏障功能，并总结文献，重点介绍紧密连接蛋白在增殖、转化和转移中的作用。
