血脑屏障中的紧密连接：结构、调控及调控物质概述。
Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances.
机构信息
Department of Pharmacology, Second Military Medical University, Shanghai, China.
出版信息
CNS Neurosci Ther. 2012 Aug;18(8):609-15. doi: 10.1111/j.1755-5949.2012.00340.x. Epub 2012 Jun 12.
Abstract
Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.
摘要
血脑屏障（BBB）是一种动态的干扰，调节中枢神经系统（CNS）内外的营养物质和有害物质，对维持 CNS 的稳定环境起着至关重要的作用。相邻细胞之间的紧密连接形成了 BBB 的基本结构，限制了细胞旁通透性。本文详细描述了紧密连接蛋白的组成，以及在刺激和病理条件下紧密连接的调节。还讨论了紧密连接调节剂。
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