Endocrinology, Diabetes & Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Rev Endocr Metab Disord. 2013 Jun;14(2):127-31. doi: 10.1007/s11154-013-9248-6.
Human Immunodeficiency virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) are associated with dysfunction of many endocrine organs and their axis. HIV infectivity leads to altered metabolism, poor oral intake and increased prevalence of weight loss and wasting which may have a role in thyroid dysfunction. Overt thyroid dysfunction occurs at similar rates as the general population while subclinical disease such as nonthyroidal illness (sick euthyroid syndrome), subclinical hypothyroidism and isolated low T4 levels are more frequent. Moreover, HAART therapy can complicate thyroid function further through drug interactions and the immune reconstitution inflammatory syndrome (IRIS). In this review we report the common thyroid dysfunctions associated with HIV before and after HAART therapy. We discuss presentation, diagnostic work up, treatment and follow up in each condition.
人类免疫缺陷病毒（HIV）感染和获得性免疫缺陷综合征（AIDS）与许多内分泌器官及其轴的功能障碍有关。HIV 感染可导致代谢改变、口腔摄入不良以及体重减轻和消耗的发生率增加，这可能与甲状腺功能障碍有关。明显的甲状腺功能障碍的发生率与普通人群相似，而亚临床疾病如非甲状腺疾病（病态甲状腺功能正常综合征）、亚临床甲状腺功能减退症和孤立性低 T4 水平更为常见。此外，HAART 治疗可能通过药物相互作用和免疫重建炎症综合征（IRIS）进一步使甲状腺功能复杂化。在这篇综述中，我们报告了与 HIV 相关的常见甲状腺功能障碍，包括 HAART 治疗前后。我们讨论了每种情况下的表现、诊断、治疗和随访。
