Scholz E, Trebing D, Knipping S
Klinik für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Plastische Operationen, Städtisches Klinikum Dessau, Dessau, Deutschland,
HNO. 2014 Apr;62(4):282-5. doi: 10.1007/s00106-013-2682-7.
Malignant tumors occur in up to 15 % of patients with paraneoplastic syndromes. The temporal association between malignancy and paraneoplasia is variable. Dermatomyositis belongs to the facultative cutaneous paraneoplasia.
A patient presented with a cervical swelling and preexisting dermatomyositis. Staging revealed a tonsillar carcinoma with cervical, mediastinal and bone metastasis, and meningeal carcinomatosis. Systemic intrathecal chemotherapy was initiated.
Dermatomyositis has only been described four times worldwide as a paraneoplastic disease with tonsillar carcinoma. Upon occurrence of a paraneoplastic syndrome, an intensive search for tumours is required at regular intervals until the primary tumor is diagnosed.
高达15%的副肿瘤综合征患者会发生恶性肿瘤。恶性肿瘤与副肿瘤之间的时间关联是可变的。皮肌炎属于兼性皮肤副肿瘤。
一名患者出现颈部肿胀且患有皮肌炎。分期检查显示为扁桃体癌伴颈部、纵隔和骨转移以及脑膜癌病。开始进行全身鞘内化疗。
皮肌炎作为伴扁桃体癌的副肿瘤性疾病在全球仅被描述过四次。一旦发生副肿瘤综合征，需要定期进行深入的肿瘤筛查，直到诊断出原发性肿瘤。
