Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
Invest Ophthalmol Vis Sci. 2013 Jul 10;54(7):4621-7. doi: 10.1167/iovs.13-11950.
To determine the prevalence and types of glaucoma in an urban Singaporean Indian population.
The Singapore Indian Eye Study (SINDI) was a population-based, cross-sectional survey that examined 3400 (75.6% response) persons aged 40 to 80 years. Participants underwent a standardized examination including slit-lamp biomicroscopy, Goldmann applanation tonometry, and dilated optic disc assessment. Participants suspected to have glaucoma also underwent visual field examination (24-2 SITA standard, Humphrey Visual Field Analyzer II), gonioscopy, and repeat applanation tonometry. Glaucoma was defined according to International Society for Geographical and Epidemiologic Ophthalmology criteria.
Of the 3400 participants, 78 (2.29%) had diagnosed glaucoma, giving an age-standardized prevalence of 1.95% (95% confidence interval [CI], 1.5%-2.5%). The age-standardized prevalence of primary open-angle glaucoma (POAG) was 1.25% (95% CI, 0.89%-1.73%), primary angle-closure glaucoma (PACG) 0.12% (95% CI, 0.04%-0.33%), and secondary glaucoma 0.55% (95% CI, 0.35%-0.86%). The mean IOP among the participants in the normal group in the study population was 15.6 ± 2.6 mm Hg and 17.7 ± 6.1 mm Hg in subjects with glaucoma (P = 0.003). The mean central corneal thickness (CCT) in the normal study population was 540.31 ± 33.79; the mean CCT in subjects with POAG (529.8 ± 30.8 μm) was statistically different from the normal study group (P = 0.003).
The prevalence of glaucoma among Singaporean Indians 40 years of age and older in Singapore was 1.95%, approximately half that of the Chinese and the Malay persons in Singapore. As in other Asian studies, POAG was the main form of glaucoma accounting for nearly 60% of cases.
确定新加坡印度裔人群中青光眼的患病率和类型。
新加坡印度人眼研究（SINDI）是一项基于人群的横断面研究，共纳入 3400 名（75.6%应答率）年龄在 40 至 80 岁的人群。参与者接受了标准化检查，包括裂隙灯生物显微镜检查、Goldmann 压平眼压测量和眼底检查。疑似青光眼的患者还接受了视野检查（24-2 SITA 标准，Humphrey 视野分析仪 II）、房角镜检查和重复压平眼压测量。青光眼的诊断依据国际眼科地理和流行病学学会的标准。
在 3400 名参与者中，78 人（2.29%）患有确诊青光眼，经年龄标准化后患病率为 1.95%（95%置信区间[CI]，1.5%-2.5%）。原发性开角型青光眼（POAG）的年龄标准化患病率为 1.25%（95%CI，0.89%-1.73%），原发性闭角型青光眼（PACG）为 0.12%（95%CI，0.04%-0.33%），继发性青光眼为 0.55%（95%CI，0.35%-0.86%）。研究人群中正常组参与者的平均眼压为 15.6±2.6mmHg，青光眼组为 17.7±6.1mmHg（P=0.003）。正常研究人群的平均中央角膜厚度（CCT）为 540.31±33.79μm；POAG 组的平均 CCT（529.8±30.8μm）与正常研究组有统计学差异（P=0.003）。
新加坡印度裔 40 岁及以上人群的青光眼患病率为 1.95%，约为新加坡华人和马来人患病率的一半。与其他亚洲研究一样，POAG 是主要的青光眼类型，占病例的近 60%。
