特应性皮炎中的共病
Comorbidity in Atopic Dermatitis.
作者信息
Simpson Eric L
机构信息
Oregon Health & Science University, Department of Dermatology, Portland, Oregon USA.
出版信息
Curr Dermatol Rep. 2012 Mar 1;1(1):29-38. doi: 10.1007/s13671-011-0003-5.
Abstract
The negative impact of atopic dermatitis (AD) often extends beyond the skin. Children with AD experience increased rates of infectious, mental health, and allergic diseases compared to their non-atopic peers. The mechanisms underlying these associations remain elusive. New insights from genetic and epidermal research pinpoint the skin barrier as a primary initiator of AD. Epicutaneous sensitization represents an intriguing new model which links a disrupted skin barrier to the later development of IgE-mediated diseases in patients with AD. Recent epidemiological studies have identified new comorbidities linked to AD as well, including several mental health disorders and obesity. This manuscript reviews the recent literature regarding both classic and newly described AD comorbidities.
摘要
特应性皮炎（AD）的负面影响往往超出皮肤范畴。与非特应性同龄人相比，患有AD的儿童患传染病、心理健康问题和过敏性疾病的几率更高。这些关联背后的机制仍不明确。遗传学和表皮研究的新见解指出皮肤屏障是AD的主要引发因素。经皮致敏是一种引人关注的新模型，它将受损的皮肤屏障与AD患者IgE介导疾病的后期发展联系起来。最近的流行病学研究还发现了与AD相关的新的合并症，包括几种心理健康障碍和肥胖症。本文综述了有关经典和新描述的AD合并症的最新文献。
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