Tham Elizabeth Huiwen, Leung Donald Ym
Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, National University Health System, Singapore.
Allergy Asthma Immunol Res. 2019 Jan;11(1):4-15. doi: 10.4168/aair.2019.11.1.4.
The Atopic march denotes the progression from atopic dermatitis (AD) to the development of other allergic disorders such as immunoglobulin (Ig) E-mediated food allergy, allergic rhinitis and asthma in later childhood. There is increasing evidence from prospective birth cohort studies that early-onset AD is a risk factor for other allergic diseases or is found in strong association with them. Animal studies now provide mechanistic insights into the pathways that may be responsible for triggering the progression from the skin barrier dysfunction seen in AD to epicutaneous sensitization, food allergy and allergic airway disorders. Recent large randomized controlled trials have demonstrated the efficacy of early interventions targeted at AD and food allergy prevention. These show great promise for research into future strategies aimed at prevention of the atopic march.
特应性进程指的是从特应性皮炎（AD）发展到在儿童后期出现其他过敏性疾病，如免疫球蛋白（Ig）E介导的食物过敏、过敏性鼻炎和哮喘。前瞻性出生队列研究越来越多地表明，早发性AD是其他过敏性疾病的危险因素，或者与它们密切相关。动物研究现在为可能导致从AD中出现的皮肤屏障功能障碍发展到表皮致敏、食物过敏和过敏性气道疾病的途径提供了机制性见解。最近的大型随机对照试验已经证明了针对AD和食物过敏预防的早期干预措施的有效性。这些研究为未来旨在预防特应性进程的策略研究带来了巨大希望。
