College of Pharmacy, Korea University, 2511 Sejongro, Sejong, 339-700, Republic of Korea.
Curr Med Chem. 2013;20(28):3488-99. doi: 10.2174/09298673113209990036.
Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.
基于普朗尼克的核/壳纳米粒子（NPs）可以通过各种策略形成，如自组装和温度诱导的相转变。为了提高其作为诊断和治疗的纳米医学的功能，可以采用囊泡融合和层层组装的方法。由于普朗尼克壳的亲水性和相对较小的尺寸，基于普朗尼克的核/壳 NPs 被用于改善药物和成像剂中的药物代谢动力学行为。本综述将根据其制备方法和形成机制介绍各种类型的基于普朗尼克的核/壳 NPs。重点将放在基于普朗尼克的核/壳 NPs 用于肿瘤靶向、蛋白质的刺激释放和癌症成像能力上。
