小花宽叶杜鹃中的一个新二萜化合物——小花宽叶杜鹃酮 A，具有一个前所未有的碳骨架。
Micranthanone A, a new diterpene with an unprecedented carbon skeleton from Rhododendron micranthum.
机构信息
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology , Wuhan 430030, Hubei, P. R. China, School of Chemistry and Chemical Engeering, Taishan Medical University , Tai-An 271016, Shandong, P. R. China, and Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences , Fuzhou 350002, Fujian, P. R. China.
出版信息
Org Lett. 2013 Jun 21;15(12):3094-7. doi: 10.1021/ol401292y. Epub 2013 Jun 7.
A new diterpene with an unprecedented carbon skeleton, micranthanone A (1), two new grayanane diterpenoids bearing an unusual 5,6-(3,4-dihydroxylbenzylidene acetal) motif, rhodomicranols A (2) and B (3), and three known grayanane diterpenoids (4-6) were isolated from Rhododendron micranthum. Their structures were elucidated by spectroscopic analyses, calculated ECD, and single-crystal X-ray diffraction. The in vitro immunomodulatory activities of 1-6 were evaluated, and a plausible biogenetic pathway for 1 is proposed.
从密枝杜鹃（Rhododendron micranthum）中分离得到一个具有全新碳骨架的新二萜化合物，密兰酮 A（1），两个具有不寻常的 5,6-（3,4-二羟基苯亚甲基）缩醛基模式的新钩状二萜，罗地密醇 A（2）和 B（3），以及三个已知的钩状二萜（4-6）。通过光谱分析、计算 ECD 和单晶 X 射线衍射确定了它们的结构。评估了 1-6 的体外免疫调节活性，并提出了 1 的可能生物发生途径。
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