一个定位于小鼠Y染色体性别决定区域的基因是一个胚胎期表达的新基因家族的成员。
A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes.
作者信息
Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Münsterberg A, Vivian N, Goodfellow P, Lovell-Badge R
机构信息
Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK.
出版信息
Nature. 1990 Jul 19;346(6281):245-50. doi: 10.1038/346245a0.
A gene mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis determination. This gene is a member of a new family of at least five mouse genes, related by an amino-acid motif showing homology to other known or putative DNA-binding domains.
在Tdy突变的XY雌性小鼠品系中，一个定位于小鼠Y染色体性别决定区域的基因被删除，并且在雄性性腺发育的一个阶段表达，这与其在睾丸决定中发挥作用相一致。该基因是一个新家族的成员，这个家族至少有五个小鼠基因，它们通过一个氨基酸基序相关联，该基序与其他已知或推定的DNA结合结构域具有同源性。
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