Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia.
Can J Physiol Pharmacol. 2013 Jun;91(6):412-20. doi: 10.1139/cjpp-2012-0352. Epub 2013 Apr 17.
Over the past 100 years, advances in pharmaceutical and medical technology have reduced the burden of communicable disease, and our appreciation of the mechanisms underlying the development of noncommunicable disease has broadened. During this time, a number of studies, both in humans and animal models, have highlighted the importance of maintaining an optimal diet during pregnancy. In particular, a number of studies support the hypothesis that suboptimal maternal protein and fat intake during pregnancy can have long-term effects on the growing fetus, and increase the likelihood of these offspring developing cardiovascular, renal, or metabolic diseases in adulthood. More recently, it has been shown that dietary intake of a number of micronutrients may offset or reverse the deleterious effects of macronutrient imbalance. Furthermore, maternal fat intake has also been identified as a major contributor to a healthy fetal environment, with a beneficial role for unsaturated fats during development as well as a beneficial impact on cell membrane physiology. Together these studies indicate that attempts to optimise maternal nutrition may prove to be an efficient and cost-effective strategy for preventing the development of cardiovascular, renal, or metabolic diseases.
在过去的 100 年中,药物和医疗技术的进步减轻了传染病的负担,我们对非传染性疾病发展机制的认识也有所拓宽。在此期间,许多在人类和动物模型中的研究都强调了在怀孕期间保持最佳饮食的重要性。特别是,一些研究支持了这样一种假设,即怀孕期间母体蛋白质和脂肪摄入不足可能对正在发育的胎儿产生长期影响,并增加这些后代在成年后患心血管、肾脏或代谢疾病的可能性。最近,研究表明,摄入多种微量营养素可能会抵消或逆转宏量营养素失衡的有害影响。此外,母体脂肪摄入也被确定为健康胎儿环境的主要贡献者,不饱和脂肪在发育过程中具有有益作用,对细胞膜生理学也有有益影响。这些研究表明,优化母体营养的尝试可能被证明是一种有效且具有成本效益的策略,可用于预防心血管、肾脏或代谢疾病的发生。