Department of Neurology, Faculty of Medicine, Pontifícia Universidade Católica de Campinas (PUC-Campinas), Campinas, SP, Brazil.
Clin Neurophysiol. 2013 Oct;124(10):1970-4. doi: 10.1016/j.clinph.2013.05.001. Epub 2013 Jun 5.
Dementia frequently occurs in Parkinson's disease (PD) but its pathophysiological basis is little known. Comparative EEG studies of Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) are still rare, but could provide knowledge on the different pathophysiological mechanisms involved. The objective of the present study was to comparatively evaluate the absolute power and coherence on the EEG for patients with AD and PDD.
This study assessed 38 adults with AD, 12 with PDD, 31 with Parkinson's disease without dementia, and 37 controls (CG) by a neurological evaluation, CERAD neuropsychological battery, executive functions tests and qEEG, calculating global absolute powers for the delta, theta, alpha and beta bands and inter- and intra-hemispheric coherences.
The delta and theta powers were highest in PDD and lowest in CG (p<0.05). The beta frontal-occipital inter-hemispheric coherence was highest in PDD (p<0.05). Whereas, alpha and beta frontal inter-hemispheric coherence was highest in PDD and lowest in AD (p<0.05).
These results suggest that qEEG power and coherence measures are different in AD and PDD.
These qEEG differences must be related to the distinct mechanisms of cortical neural connections in AD and PDD.
帕金森病（PD）常伴有痴呆，但其病理生理学基础知之甚少。阿尔茨海默病（AD）和帕金森病痴呆（PDD）的比较脑电图研究仍然很少，但可以提供不同病理生理学机制的知识。本研究的目的是比较评估 AD 和 PDD 患者的脑电图绝对功率和相干性。
本研究通过神经学评估、CERAD 神经心理学量表、执行功能测试和 qEEG 评估了 38 名 AD 患者、12 名 PDD 患者、31 名无痴呆帕金森病患者和 37 名对照组（CG），计算了 delta、theta、alpha 和 beta 频段的总绝对功率和跨/半球相干性。
PDD 的 delta 和 theta 功率最高，CG 最低（p<0.05）。PDD 的额叶-枕叶 beta 跨半球相干性最高（p<0.05）。而 PDD 的 alpha 和 beta 额叶-半球相干性最高，AD 最低（p<0.05）。
这些结果表明 qEEG 功率和相干性测量在 AD 和 PDD 中不同。
这些 qEEG 差异必须与 AD 和 PDD 中皮质神经连接的不同机制有关。
