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ROS 的另一面：结直肠癌细胞干细胞扩增的驱动因素。

The other face of ROS: a driver of stem cell expansion in colorectal cancer.

机构信息

Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy.

出版信息

Cell Stem Cell. 2013 Jun 6;12(6):635-6. doi: 10.1016/j.stem.2013.05.023.

DOI:10.1016/j.stem.2013.05.023
PMID:23746969
Abstract

APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.

摘要

APC 突变导致 Wnt 激活在结直肠癌中很常见，但促进肿瘤发生的下游途径尚不清楚。在本期《Cell Stem Cell》杂志上，Myant 等人（2013 年）表明，Rac1 的激活通过 ROS 产生和 NF-κB 激活，是 Wnt 驱动的 Lgr5+肠干细胞转化所必需的。

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