18FDG PET-CT 用于检测胃癌手术后复发：一项荟萃分析。
18FDG PET-CT for detecting gastric cancer recurrence after surgical resection: a meta-analysis.
机构信息
Department of Medicine, Tumor Hospital Affiliated to Zhengzhou University, Dongming Road, Zhengzhou 450000, China.
出版信息
Surg Oncol. 2013 Sep;22(3):162-6. doi: 10.1016/j.suronc.2013.05.001. Epub 2013 Jun 5.
BACKGROUND
We performed a meta-analysis to evaluate the value of (18)FDG PET-CT for the detection of gastric cancer recurrence after surgical resection.
METHODS
A systematic literature search was performed in the MEDLINE and EMBASE databases. We calculated the sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio for (18)FDG PET-CT. We also constructed summary receiver operating characteristic curves for (18)FDG PET-CT.
RESULTS
Eight studies (500 patients) were included. The sensitivity, specificity, positive likelihood ratio and negative likelihood ratio of (18)FDG PET-CT were 0.86 (95% confidence interval [CI] = 0.71-0.94), 0.88 (95% CI = 0.75-0.94), 17.0 (95% CI = 3.5-14.0), and 0.16 (95% CI = 0.07-0.34), respectively. Overall weighted area under the curve was 0.93 (95% CI = 0.91-0.95).
CONCLUSIONS
(18)FDG PET-CT has moderate sensitivity and specificity for detection of gastric cancer recurrence after surgical resection.
背景
我们进行了一项荟萃分析，以评估（18）FDG PET-CT 在检测胃癌手术后复发中的价值。
方法
我们在 MEDLINE 和 EMBASE 数据库中进行了系统的文献检索。我们计算了（18）FDG PET-CT 的敏感性、特异性、阳性似然比和阴性似然比。我们还为（18）FDG PET-CT 构建了综合受试者工作特征曲线。
结果
共纳入 8 项研究（500 例患者）。（18）FDG PET-CT 的敏感性、特异性、阳性似然比和阴性似然比分别为 0.86（95%置信区间[CI] = 0.71-0.94）、0.88（95% CI = 0.75-0.94）、17.0（95% CI = 3.5-14.0）和 0.16（95% CI = 0.07-0.34）。总体加权曲线下面积为 0.93（95% CI = 0.91-0.95）。
结论
（18）FDG PET-CT 对检测胃癌手术后复发具有中等的敏感性和特异性。
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