Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ann Thorac Surg. 2013 Jul;96(1):339-45. doi: 10.1016/j.athoracsur.2012.12.060. Epub 2013 Jun 5.
Research on the therapeutic modulation of cardiac autonomic tone by electrical stimulation has yielded encouraging early clinical results. Vagus nerve stimulation has reduced the rates of morbidity and sudden death from heart failure, but therapeutic vagus nerve stimulation is limited by side effects of hypotension and bradycardia. Sympathetic nerve stimulation that has been implemented in the experiment may exacerbate the sympathetic-dominated autonomic imbalance. In contrast, concurrent stimulation of both sympathetic and parasympathetic cardiac nerves increases myocardial contractility without increasing heart rate. This review assesses the current state of electrical stimulation of the cardiac autonomic nervous system to treat heart failure.
心脏自主神经张力的电刺激治疗调节研究已经取得了令人鼓舞的早期临床结果。迷走神经刺激降低了心力衰竭发病率和猝死率，但治疗性迷走神经刺激受到低血压和心动过缓副作用的限制。已在实验中实施的交感神经刺激可能会加剧占主导地位的交感神经自主神经失衡。相比之下，同时刺激交感神经和副交感神经心脏神经会增加心肌收缩力而不增加心率。本综述评估了心脏自主神经系统电刺激治疗心力衰竭的现状。
