Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Virology. 2013 Aug 15;443(1):106-12. doi: 10.1016/j.virol.2013.04.027. Epub 2013 Jun 5.
HIV-1 and HTLV-1 can infect CD4+ T cells and can co-infect the same individual. In principle, it is possible that both viruses can infect the same CD4+ T cells in dually infected persons. Currently, how efficiently HTLV-1 and HIV-1 co-infects the same cell and the full extent of their biological interactions are not well-understood. Here, we report evidence confirming that both viruses can infect the same cells and that HTLV-1 envelope (Env) can pseudotype HIV-1 viral particles and HIV-1 envelope (Env) can pseudotype HTLV-1 virions to mediate subsequent infections of substrate cells. We also show that the construction of a chimeric HTLV-1 molecular clone carrying the HIV-1 Env in place of its HTLV-1 counterpart results in a replication competent moiety. These findings raise new implications of viral complementation and assortment between HIV-1 and HTLV-1 in dually infected persons.
HIV-1 和 HTLV-1 均可感染 CD4+T 细胞，并且可以同时感染同一个体。原则上，两种病毒有可能同时感染双重感染个体的同一 CD4+T 细胞。目前，尚不清楚 HTLV-1 和 HIV-1 同时感染同一细胞的效率以及它们之间的全部生物学相互作用。在这里，我们报告了证据，证实两种病毒均可感染同一细胞，并且 HTLV-1 包膜（Env）可以假型化 HIV-1 病毒颗粒，而 HIV-1 包膜（Env）可以假型化 HTLV-1 病毒颗粒，从而介导随后对基质细胞的感染。我们还表明，构建携带 HIV-1 Env 的嵌合 HTLV-1 分子克隆可替代其 HTLV-1 对应物，从而产生具有复制能力的部分。这些发现提出了在双重感染个体中 HIV-1 和 HTLV-1 之间病毒互补和分类的新含义。
