缺氧诱导的兴奋：低氧血症如何通过瓦博格效应激活先天免疫。
Agitation by suffocation: how hypoxia activates innate immunity via the Warburg effect.
机构信息
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Cell Metab. 2013 Jun 4;17(6):814-815. doi: 10.1016/j.cmet.2013.05.016.
A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.
缺氧微环境可以增强先天免疫细胞的功能；然而，其机制尚不清楚。Tannahill 等人（2013 年）发现，在巨噬细胞中，三羧酸循环中间代谢产物琥珀酸的积累稳定了转录因子 HIF-1α，从而导致促炎细胞因子 IL-1β的激活。
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