Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA; Howard Hughes Medical Institute.
Cell Metab. 2013 Jun 4;17(6):873-882. doi: 10.1016/j.cmet.2013.05.011.
The study of the intersection of immunology and metabolism is a growing field fueled by the increased prevalence of obesity-associated pathologies. Importantly, the capacity of the innate immune system to sense metabolic stress induced by nutritional surplus has been linked with the progression of obesity, insulin resistance, type 2 diabetes mellitus, nonalcoholic fatty liver disease, and atherosclerosis. Moreover, it is clear that the innate immune system regulates the composition of the intestinal microbiota, which impacts multiple host metabolic processes. Here we review recent studies in this emerging field with an emphasis on how innate immune receptors determine metabolic disease progression.
免疫与代谢的交叉研究是一个日益增长的领域，这主要归因于肥胖相关病理的普遍增加。重要的是，先天免疫系统对营养过剩引起的代谢应激的感知能力与肥胖、胰岛素抵抗、2 型糖尿病、非酒精性脂肪性肝病和动脉粥样硬化的进展有关。此外，先天免疫系统调节肠道微生物组的组成，从而影响多种宿主代谢过程，这一点已很明确。在此，我们对这一新兴领域的最新研究进行综述，重点介绍先天免疫受体如何决定代谢性疾病的进展。
