微生物诱导肥胖的途径。
Pathways in microbe-induced obesity.
机构信息
Department of Microbiology, New York University Sackler Institute of Graduate Biomedical Sciences, New York, NY 10016, USA.
Department of Microbiology, New York University Sackler Institute of Graduate Biomedical Sciences, New York, NY 10016, USA; Department of Medicine, New York University School of Medicine, New York, NY 10016, USA; Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.
出版信息
Cell Metab. 2013 Jun 4;17(6):883-894. doi: 10.1016/j.cmet.2013.05.004.
Abstract
Diet, host gene composition, and alterations in the intestinal microbiota can contribute to obesity. In microbe-induced obesity, metabolic changes stem from primary perturbation of the microbiota, consequent to modern changes in human biology. Microbiota disruption during early development can result in syndromes of metabolic dysfunction. We focus on the pathways involved in these interactions, particularly related to energy extraction and the role of inflammation in the metabolic phenotypes. Model physiologic systems and perturbations including gastric bypass surgery, pregnancy, and hibernation provide insight into the respective roles of the critical participants.
摘要
饮食、宿主基因组成和肠道微生物群的改变都可能导致肥胖。在微生物诱导的肥胖中，代谢变化源于微生物群的主要扰动，这是人类生物学现代变化的结果。早期发育过程中的微生物群破坏可导致代谢功能障碍综合征。我们专注于这些相互作用涉及的途径，特别是与能量提取和炎症在代谢表型中的作用相关的途径。模型生理系统和干扰，包括胃旁路手术、妊娠和冬眠，为关键参与者各自的作用提供了深入了解。
相似文献
1
Pathways in microbe-induced obesity.微生物诱导肥胖的途径。
Cell Metab. 2013 Jun 4;17(6):883-894. doi: 10.1016/j.cmet.2013.05.004.
2
Functional interactions between the gut microbiota and host metabolism.肠道微生物群与宿主代谢的功能相互作用。
Nature. 2012 Sep 13;489(7415):242-9. doi: 10.1038/nature11552.
3
Gut microbiota and metabolic syndrome.肠道微生物群与代谢综合征
World J Gastroenterol. 2014 Nov 21;20(43):16079-94. doi: 10.3748/wjg.v20.i43.16079.
4
[Physiological patterns of intestinal microbiota. The role of dysbacteriosis in obesity, insulin resistance, diabetes and metabolic syndrome].[肠道微生物群的生理模式。肠道菌群失调在肥胖、胰岛素抵抗、糖尿病和代谢综合征中的作用]
Orv Hetil. 2016 Jan 3;157(1):13-22. doi: 10.1556/650.2015.30296.
5
Influence of intestinal microbiota on body weight gain: a narrative review of the literature.肠道微生物群对体重增加的影响：文献综述
Obes Surg. 2015 Feb;25(2):346-53. doi: 10.1007/s11695-014-1525-2.
6
Nutritional modulation of gut microbiota - the impact on metabolic disease pathophysiology.肠道微生物群的营养调节——对代谢疾病病理生理学的影响
J Nutr Biochem. 2016 Feb;28:191-200. doi: 10.1016/j.jnutbio.2015.08.013. Epub 2015 Aug 20.
7
Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.在关键发育窗口期改变肠道微生物群会产生持久的代谢后果。
Cell. 2014 Aug 14;158(4):705-721. doi: 10.1016/j.cell.2014.05.052.
8
Intestinal microbiota and obesity.肠道微生物群与肥胖
Handb Exp Pharmacol. 2012(209):251-73. doi: 10.1007/978-3-642-24716-3_11.
9
Obesity, fatty liver disease and intestinal microbiota.肥胖、脂肪肝疾病与肠道微生物群
World J Gastroenterol. 2014 Nov 28;20(44):16452-63. doi: 10.3748/wjg.v20.i44.16452.
10
Gut microbiota and energy balance: role in obesity.肠道微生物群与能量平衡：在肥胖中的作用
Proc Nutr Soc. 2015 Aug;74(3):227-34. doi: 10.1017/S0029665114001700. Epub 2014 Dec 18.
引用本文的文献
1
Neonatal infection with affects stomach and colon microbiome composition and gene expression in mice.新生儿感染 影响小鼠的胃和结肠微生物群组成及基因表达。 （注：原文中“with”后面缺少具体感染因素，翻译可能会有信息不完整之感）
bioRxiv. 2025 May 5:2025.04.30.650706. doi: 10.1101/2025.04.30.650706.
2
Gut-immune-brain interactions during neurodevelopment: from a brain-centric to a multisystem perspective.神经发育过程中的肠道-免疫-脑相互作用：从以脑为中心到多系统视角
BMC Med. 2025 May 6;23(1):263. doi: 10.1186/s12916-025-04093-z.
3
Early-life antibiotic exposure aggravates hepatic steatosis through enhanced endotoxemia and lipotoxic effects driven by gut .早年抗生素暴露通过增强肠道驱动的内毒素血症和脂毒性作用加重肝脂肪变性。
MedComm (2020). 2025 Feb 17;6(3):e70104. doi: 10.1002/mco2.70104. eCollection 2025 Mar.
4
Effects of cottonseed meal protein hydrolysate on intestinal microbiota of yellow-feather broilers.棉籽粕蛋白水解物对黄羽肉鸡肠道微生物群的影响。
Front Microbiol. 2024 Sep 18;15:1434252. doi: 10.3389/fmicb.2024.1434252. eCollection 2024.
5
Correlated Responses to Selection for Intramuscular Fat on the Gut Microbiome in Rabbits.家兔肠道微生物群对肌内脂肪选择的相关反应。
Animals (Basel). 2024 Jul 16;14(14):2078. doi: 10.3390/ani14142078.
6
Effect of glyphosate, its metabolite AMPA, and the glyphosate formulation Roundup on brown trout ( f. ) gut microbiome diversity.草甘膦及其代谢物氨甲基膦酸（AMPA）以及草甘膦制剂农达对褐鳟肠道微生物群多样性的影响。
Front Microbiol. 2024 Jan 15;14:1271983. doi: 10.3389/fmicb.2023.1271983. eCollection 2023.
7
The Role of the Gut Microbiota in Anorexia Nervosa in Children and Adults-Systematic Review.肠道微生物群在儿童和成人神经性厌食症中的作用——系统评价。
Int J Mol Sci. 2023 Dec 19;25(1):41. doi: 10.3390/ijms25010041.
8
Relationships between diet and gut microbiome in an Italian and Dutch cohort: does the dietary protein to fiber ratio play a role?饮食与肠道微生物群在意大利和荷兰队列中的关系：饮食蛋白质与纤维的比例是否起作用？
Eur J Nutr. 2024 Apr;63(3):741-750. doi: 10.1007/s00394-023-03308-4. Epub 2023 Dec 27.
9
Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes.肥胖诱导的肠道和脂肪组织生态失调在2型糖尿病中的最新见解。
Front Mol Biosci. 2023 Sep 28;10:1224982. doi: 10.3389/fmolb.2023.1224982. eCollection 2023.
10
A Review of the Anti-Obesity Effects of Wild Edible Plants in the Mediterranean Diet and Their Active Compounds: From Traditional Uses to Action Mechanisms and Therapeutic Targets.地中海饮食中野生食用植物的抗肥胖作用及其活性成分的综述：从传统用途到作用机制和治疗靶点。
Int J Mol Sci. 2023 Aug 10;24(16):12641. doi: 10.3390/ijms241612641.
本文引用的文献
1
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.阿克曼氏菌与肠道上皮细胞的串扰控制饮食诱导的肥胖。
Proc Natl Acad Sci U S A. 2013 May 28;110(22):9066-71. doi: 10.1073/pnas.1219451110. Epub 2013 May 13.
2
Association of caesarean delivery with child adiposity from age 6 weeks to 15 years.剖宫产与儿童从 6 周龄到 15 岁时肥胖的关联。
Int J Obes (Lond). 2013 Jul;37(7):900-6. doi: 10.1038/ijo.2013.49. Epub 2013 Apr 8.
3
U.S. outpatient antibiotic prescribing, 2010.2010年美国门诊抗生素处方情况
N Engl J Med. 2013 Apr 11;368(15):1461-2. doi: 10.1056/NEJMc1212055.
4
Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity.由于胃旁路手术导致的肠道微生物组的保守变化会减轻宿主的体重和肥胖程度。
Sci Transl Med. 2013 Mar 27;5(178):178ra41. doi: 10.1126/scitranslmed.3005687.
5
Biphasic assembly of the murine intestinal microbiota during early development.在早期发育过程中，鼠类肠道微生物群的两相组装。
ISME J. 2013 Jun;7(6):1112-5. doi: 10.1038/ismej.2013.15. Epub 2013 Mar 28.
6
Caesarean delivery, caesarean delivery on maternal request and childhood overweight: a Chinese birth cohort study of 181 380 children.剖宫产、产妇要求下的剖宫产与儿童超重：一项对181380名儿童的中国出生队列研究。
Pediatr Obes. 2014 Feb;9(1):10-6. doi: 10.1111/j.2047-6310.2013.00151.x. Epub 2013 Mar 19.
7
Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing.肠道微生物通过单细胞稳定同位素探测进行宿主化合物觅食。
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4720-5. doi: 10.1073/pnas.1219247110. Epub 2013 Mar 4.
8
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.遗传控制肥胖和肠道微生物组成对高脂肪、高蔗糖饮食的响应在小鼠中。
Cell Metab. 2013 Jan 8;17(1):141-52. doi: 10.1016/j.cmet.2012.12.007.
9
Immunology of the maternal-fetal interface.母胎界面的免疫学
Annu Rev Immunol. 2013;31:387-411. doi: 10.1146/annurev-immunol-032712-100003. Epub 2013 Jan 3.
10
High-level colonisation of the human gut by Verrucomicrobia following broad-spectrum antibiotic treatment.广谱抗生素治疗后，厚壁菌门在人类肠道中的高定植。
Int J Antimicrob Agents. 2013 Feb;41(2):149-55. doi: 10.1016/j.ijantimicag.2012.10.012. Epub 2013 Jan 5.
Zotero 插件