微生物诱导肥胖的途径。
Pathways in microbe-induced obesity.
机构信息
Department of Microbiology, New York University Sackler Institute of Graduate Biomedical Sciences, New York, NY 10016, USA.
Department of Microbiology, New York University Sackler Institute of Graduate Biomedical Sciences, New York, NY 10016, USA; Department of Medicine, New York University School of Medicine, New York, NY 10016, USA; Medical Service, VA New York Harbor Healthcare System, New York, NY 10010, USA.
出版信息
Cell Metab. 2013 Jun 4;17(6):883-894. doi: 10.1016/j.cmet.2013.05.004.
Diet, host gene composition, and alterations in the intestinal microbiota can contribute to obesity. In microbe-induced obesity, metabolic changes stem from primary perturbation of the microbiota, consequent to modern changes in human biology. Microbiota disruption during early development can result in syndromes of metabolic dysfunction. We focus on the pathways involved in these interactions, particularly related to energy extraction and the role of inflammation in the metabolic phenotypes. Model physiologic systems and perturbations including gastric bypass surgery, pregnancy, and hibernation provide insight into the respective roles of the critical participants.
饮食、宿主基因组成和肠道微生物群的改变都可能导致肥胖。在微生物诱导的肥胖中，代谢变化源于微生物群的主要扰动，这是人类生物学现代变化的结果。早期发育过程中的微生物群破坏可导致代谢功能障碍综合征。我们专注于这些相互作用涉及的途径，特别是与能量提取和炎症在代谢表型中的作用相关的途径。模型生理系统和干扰，包括胃旁路手术、妊娠和冬眠，为关键参与者各自的作用提供了深入了解。
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