Wallenberg Laboratory for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital, 413 45 Gothenburg, Sweden.
Nature. 2012 Sep 13;489(7415):242-9. doi: 10.1038/nature11552.
The link between the microbes in the human gut and the development of obesity, cardiovascular disease and metabolic syndromes, such as type 2 diabetes, is becoming clearer. However, because of the complexity of the microbial community, the functional connections are less well understood. Studies in both mice and humans are helping to show what effect the gut microbiota has on host metabolism by improving energy yield from food and modulating dietary or the host-derived compounds that alter host metabolic pathways. Through increased knowledge of the mechanisms involved in the interactions between the microbiota and its host, we will be in a better position to develop treatments for metabolic disease.
人类肠道中的微生物与肥胖、心血管疾病和代谢综合征（如 2 型糖尿病）的发展之间的联系越来越清晰。然而，由于微生物群落的复杂性，其功能联系还不太清楚。在小鼠和人类中的研究正在帮助我们了解肠道微生物群对宿主代谢的影响，方法是提高食物的能量产量，并调节改变宿主代谢途径的饮食或宿主来源的化合物。通过增加对微生物与其宿主之间相互作用的机制的了解，我们将能够更好地开发治疗代谢疾病的方法。
