Department of Neurosurgery & Brain Repair, University of South Florida, Tampa, FL, USA.
Epilepsy Behav. 2013 Aug;28(2):181-4. doi: 10.1016/j.yebeh.2013.04.015. Epub 2013 Jun 7.
We present, to our knowledge, the first published series of corpus callosotomy (CC) in adults with medically intractable symptomatic generalized epilepsy (SGE). Fifteen adults were followed for the outcome measures of seizure and antiepileptic drug (AED) burden and quality of life (QoL). Five (33%) patients reported >60%, one (7%) reported between 30 and 60%, and nine (60%) reported <30% reduction in the total number of seizures after CC. Seven (47%) patients reported >60%, three (20%) experienced between 30 and 60%, and five (33%) reported <30% atonic seizure reduction. Twelve patients had no change in AED burden. Nine (60%) patients had no change in QoL, while six (40%) reported some improvement. Corpus callosotomy should be considered as a safe option for adults with medically intractable SGE with demonstrated reduction in the frequency of atonic seizures, and some patients experience a meaningful improvement in quality of life.
我们报告了，据我们所知，第一组成人药物难治性症状性全面性癫痫（SGE）胼胝体切开术（CC）的系列病例。对 15 名成年人进行了随访，以评估发作和抗癫痫药物（AED）负担以及生活质量（QoL）的结果。5 名（33%）患者报告 >60%，1 名（7%）报告 30%至 60%之间，9 名（60%）报告 <30%的总发作次数减少。7 名（47%）患者报告 >60%，3 名（20%）经历 30%至 60%之间，5 名（33%）报告 <30%的猝倒发作减少。12 名患者的 AED 负担无变化。9 名（60%）患者的生活质量无变化，而 6 名（40%）患者报告有所改善。胼胝体切开术应被视为药物难治性 SGE 成人患者的一种安全选择，可降低猝倒发作的频率，并且一些患者的生活质量有明显改善。
